Anti-SERPING1 Antibody (CAB19259)

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SKU:
CAB19259
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
SERPING1
Synonyms:
C1IN
Synonyms:
C1INH
Synonyms:
C1NH
Synonyms:
HAE1
Synonyms:
HAE2
Synonyms:
serpin family G member 1
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Description

I抗体名:SERPING1 Rabbit mAb
抗体コード:CAB19259
サイズ:20uL, 50uL, 100uL
同義語:SERPING1, C1IN, C1INH, C1NH, HAE1, HAE2, serpin family G member 1
申し込み:WB
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant protein of human SERPING1.
申し込み:WB
推奨される希釈:WB 1:500 - 1:2000
反応性:Human, Mouse, Rat
免疫原:Recombinant protein of human SERPING1.
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:710
Uniprot:P05155
セルラーロケーション:Secreted
計算された分子量:100kDa
観察された分子量:Refer to figures
UniProt Protein Function:SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: extracellular space; extracellular region

Molecular Function:serine-type endopeptidase inhibitor activity; protein binding

Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; fibrinolysis; platelet degranulation; blood circulation; innate immune response; blood coagulation; complement activation, classical pathway; blood coagulation, intrinsic pathway; aging

Disease: Complement Component 4, Partial Deficiency Of; Angioedema, Hereditary, Type I

NCBI Summary:This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]
UniProt Code:P05155
NCBI GenInfo Identifier:124096
NCBI Gene ID:710
NCBI Accession:P05155.2
UniProt Secondary Accession:P05155,Q16304, Q547W3, Q59EI5, Q7Z455, Q96FE0, Q9UC49 A6NMU0, A8KAI9, B2R6L5, B4E1F0, B4E1H2,
UniProt Related Accession:P05155
Molecular Weight:
NCBI Full Name:Plasma protease C1 inhibitor
NCBI Synonym Full Names:serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
NCBI Official Symbol:SERPING1  
NCBI Official Synonym Symbols:C1IN; C1NH; HAE1; HAE2; C1INH  
NCBI Protein Information:plasma protease C1 inhibitor; serpin G1; C1-inhibiting factor; C1 esterase inhibitor; complement component 1 inhibitor; serine/cysteine proteinase inhibitor clade G member 1
UniProt Protein Name:Plasma protease C1 inhibitor
UniProt Synonym Protein Names:C1 esterase inhibitor; C1-inhibiting factor; Serpin G1
Protein Family:Para-Rep
UniProt Gene Name:SERPING1  
UniProt Entry Name:IC1_HUMAN
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