[KO Validated] TLK2 Rabbit Polyclonal Antibody (CAB6770)

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SKU:
CAB6770
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle
Reactivity:
Human, Mouse
Synonyms:
HsHPK, MRD57, PKU-ALPHA, K2
Research Use:
Cell Cycle
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Description

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[KO Validated] TLK2 Antibody (CAB6770)

The [KO Validated] TLK2 Antibody (CAB6770) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting TLK2 in human samples, making it ideal for Western blot applications.TLK2, a serine/threonine kinase, plays a crucial role in maintaining genomic stability and ensuring proper DNA replication. Dysregulation of TLK2 has been linked to various diseases, including cancer, making it a promising target for therapeutic interventions.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.

Product Name:[KO Validated] TLK2 Antibody
SKU:CAB6770
Size:20μL, 100μL
Reactivity:Human, Mouse
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MMEE LHSL DPRR QELL EARF TGVG VSKG PLNS ESSN QSLC SVGS LSDK EVET PEKK QNDQ RNRK RKAE PYET SQGK GTPR GHKI SDYF EFAG GSAP GTSP GRSV PPVA RSSP QHSL SNPL PRRV EQPL YGLD GSAA KEAT EEQS ALPT LMSV MLAK PRLD TEQL AQRG AGLC FTFV SAQQ NSPS STGS GNTE HSCS SQKQ ISIQ HRQT QSDL TIEK ISAL
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:HsHPK, MRD57, PKU-ALPHA, K2
Positive Sample:293T, Mouse testis, NIH/3T3
Cellular Localization:Cytoplasm, Nucleus, Cytoskeleton, Perinuclear Region.
Calculated MW:88kDa
Observed MW:87kDa

This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants.

Purification MethodAffinity purification
Gene ID11011
RRIDAB_2767353
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using [KO Validated] TLK2 Rabbit pAb (CAB6770) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 90s.
Product ImageWestern blot analysis of lysates from wild type (WT) and TLK2 knockout (KO) NIH/3T3 cells, using [KO Validated] TLK2 Rabbit pAb (CAB6770) at 1:500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 180s.
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