CXCL10 Rabbit Polyclonal Antibody (CAB1457)

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SKU:
CAB1457
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Synonyms:
C7, IFI10, INP10, IP-10, crg-2, mob-1, SCYB10, gIP-10, CXCL10/IP-10
Research Use:
Cell Biology
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Description

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CXCL10 Antibody (CAB1457)

The CXCL10 Antibody (CAB1457) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is specifically designed to target the CXCL10 protein, allowing for accurate detection and analysis in various experimental settings, including Western blot applications.CXCL10, also known as interferon-gamma-induced protein 10 (IP-10), is a key player in recruiting immune cells to sites of inflammation and promoting anti-tumor immunity. Its dysregulation has been implicated in various diseases, including autoimmune disorders, infectious diseases, and cancer.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.

Product Name:CXCL10 Antibody
SKU:CAB1457
Size:20μL, 100μL
Reactivity:Human
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:QGVP LSRT VRCT CISI SNQP VNPR SLEK LEII PASQ FCPR VEII ATMK KKGE KRCL NPES KAIK NLLK AVSK ERSK RSP
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:C7, IFI10, INP10, IP-10, crg-2, mob-1, SCYB10, gIP-10, CXCL10/IP-10
Positive Sample:HeLa, THP-1+IFN-γ+LPS+BFA
Cellular Localization:Secreted.
Calculated MW:11kDa
Observed MW:11kDa

This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. This gene may also be a key regulator of the 'cytokine storm' immune response to SARS-CoV-2 infection.

Purification MethodAffinity purification
Gene ID3627
RRIDAB_2761445
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of lysates from THP-1 cells using CXCL10/IP-10 Rabbit pAb (CAB1457) at 1:2000 dilution incubated overnight at 4℃. THP-1 cells were treated with IFN-γ (200ng/ml) at 37℃ for 24 hours,LPS (50ng/ml) at 37℃ for 24 hours and BFA (5ug/ml ) at 37℃ for 21 hours. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 30 μg per lane. Blocking buffer: 3 % nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 20s.
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