Anti-GABAA Receptor Alpha 4 Antibody [N398A/34 (Formerly sold as S398A-34)]

GABAA Receptor Alpha 4 Antibody [N398A/34 (Formerly sold as S398A-34)]

GABAA Receptor Alpha 4 Antibody [N398A/34 (Formerly sold as S398A-34)] is a mouse monoclonal antibody directed against GABAA Receptor Alpha 4, offered by Assay Genie for research applications. Reported applications include WB, IHC and ICC/IF. Reported reactivity: Human, Mouse and Rat. Supplied as IgG1, purified by Protein G.

The GABA-A receptor alpha 4 subunit (GABRA4) is a key component of the GABA-A receptor complex, the primary mediator of fast inhibitory neurotransmission in the central nervous system. As part of the ligand-gated ion channel superfamily, GABRA4 contributes to tonic inhibition, particularly in the thalamus and hippocampus—regions essential for cognition, memory, and seizure regulation. Dysregulation of GABRA4 has been strongly linked to epilepsy and pharmacoresistance to antiepileptic drugs, highlighting its role in maintaining neural circuit stability. Beyond epilepsy, emerging evidence suggests that GABRA4 dysfunction may contribute to the pathophysiology of neurodegenerative diseases by disrupting inhibitory-excitatory balance, promoting network hyperexcitability, and impairing synaptic plasticity. These mechanisms are increasingly recognized in conditions such as Alzheimer’s disease, where altered GABAergic signaling is associated with cognitive decline and neuronal vulnerability. As a result, GABRA4 is gaining attention as a potential biomarker and therapeutic target in neurodegeneration. Advancing our understanding of GABRA4’s role in inhibitory signaling may unlock new strategies for early intervention and disease modification in disorders characterized by GABAergic dysfunction. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.