Anti-GABAA Receptor Alpha 1 Antibody [N95/35 (Formerly sold as S95-35)]

GABAA Receptor Alpha 1 Antibody [N95/35 (Formerly sold as S95-35)]

GABAA Receptor Alpha 1 Antibody [N95/35 (Formerly sold as S95-35)] is a mouse monoclonal antibody directed against GABAA Receptor Alpha 1, offered by Assay Genie for research applications. Reported applications include WB, IHC, ICC/IF and AM. Reported reactivity: Human, Mouse and Rat. Supplied as IgG2A, purified by Protein G.

The GABA A receptor alpha 1 subunit (GABRA1) is a critical component of the GABA A receptor complex, a family of fast-acting ligand-gated ion channels that mediate the majority of rapid inhibitory neurotransmission in the central nervous system. These receptors are pentameric structures composed of various subunits, with the alpha 1 subunit being the most abundantly expressed in the adult brain. GABRA1 plays a central role in maintaining synaptic inhibition, regulating neuronal excitability, and shaping network oscillations essential for cognitive and behavioral functions. Emerging evidence links GABRA1 dysfunction to the pathophysiology of several neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. Altered expression or function of the alpha 1 subunit has been associated with key features of neurodegeneration, such as disrupted inhibitory signaling, synaptic imbalance, and increased neuronal vulnerability. As such, GABRA1 is gaining attention as a potential biomarker and therapeutic target in the early detection and treatment of these disorders. Advancements in molecular imaging, transcriptomics, and electrophysiology are enhancing our understanding of GABRA1’s spatial distribution and functional dynamics in both healthy and diseased brains. These insights are crucial for developing targeted interventions aimed at restoring inhibitory tone and preserving neural circuitry in neurodegenerative conditions. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.