XPC Rabbit Polyclonal Antibody (CAB8354)

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SKU:
CAB8354
Product Type:
Antibody
Applications:
WB
Applications:
IHC
Applications:
IP
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
Antibody Type:
Polyclonal Antibody
Synonyms:
XP3, RAD4, XPCC, p125, XPC
Research Use:
Epigenetics and Nuclear Signaling
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Description

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XPC Antibody (CAB8354)

The XPC Antibody (CAB8354) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high specificity for human samples and is validated for use in Western blot applications. By binding to the XPC protein, it allows for the detection and analysis of XPC expression in a variety of cell types.XPC is essential for the recognition and repair of damaged DNA, making it crucial for maintaining genomic stability and preventing mutations that can lead to cancer and other diseases.

This antibody is validated for use in WB, IHC-P, IP, ELISA applications and has demonstrated reactivity against Human samples.

Product Name:XPC Antibody
SKU:CAB8354
Size:20μL, 100μL
Reactivity:Human
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:GEVP YKMV KGFS NRAR KARL AEPQ LREE NDLG LFGY WQTE EYQP PVAV DGKV PRNE FGNV YLFL PSMM PIGC VQLN LPNL HRVA RKLD IDCV QAIT GFDF HGGY SHPV TDGY IVCE EFKD VLLT AWEN EQAV IERK EKEK KEKR ALGN WKLL AKGL LIRE RLKR RYGP KSEA AAPH TDAG GGLS SDEE EGTS SQAE AARI LAAS WPQN REDE EKQK LKGG PKKT KREK KAAA SHLF PFEQ L
Tested Applications:WB IHC-P IP ELISA
Recommended Dilution:
WB1:500 - 1:2000
IHC-P1:50 - 1:200
IP0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:XP3, RAD4, XPCC, p125, XPC
Positive Sample:LO2, HeLa, 293T, HT-1080, Jurkat
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:106kDa
Observed MW:130kDa

The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

Purification MethodAffinity purification
Gene ID7508
RRIDAB_2772922
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using XPC Rabbit pAb (CAB8354) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 5s.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human colon carcinoma using XPC Rabbit pAb (CAB8354) at dilution of 1:100 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
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