The TEK Antibody (CAB7222) is a high-quality antibody developed for reliable detection and analysis of target proteins. The antibody, produced in rabbits, is specifically designed for use in Western blot applications and is proven to react strongly with human samples.TEK, also known as TIE2, is a receptor tyrosine kinase that plays a crucial role in vascular development and angiogenesis. Dysregulation of TEK has been implicated in various diseases, including cancer, cardiovascular disorders, and inflammatory conditions. By targeting TEK, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially develop novel therapeutic strategies.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
TEK Antibody
SKU:
CAB7222
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
TIE2, VMCM, GLC3E, TIE-2, VMCM1, CD202B, TEK
Positive Sample:
ECV-304
Cellular Localization:
Cell Junction, Cell Membrane, Cytoplasm, Secreted, Single-Pass Type I Membrane Protein, Cytoskeleton, Focal Adhesion.
Calculated MW:
126kDa
Observed MW:
126kDa
This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Purification Method
Affinity purification
Gene ID
7010
RRID
AB_2767771
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using TEK Rabbit pAb (CAB7222) at 1:500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
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