Survivin Monoclonal Antibody (CAB22034)

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SKU:
CAB22034
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
Synonyms:
API4, EPR-1, Survivin
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Description

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Survivin Monoclonal Antibody (CAB22034)

The Survivin Monoclonal Antibody (CAB22034) is a high-quality antibody developed for reliable detection and analysis of target proteins. This monoclonal antibody is specifically designed to target survivin in human samples, providing reliable results for a variety of research applications, including immunohistochemistry and flow cytometry.Survivin is a unique protein that regulates cell division and inhibits apoptosis, making it a highly interesting target for cancer research. Studies have shown that survivin is overexpressed in many types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis and resistance to chemotherapy.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.

Product Name:Survivin Monoclonal Antibody
SKU:CAB22034
Size:20μL, 100μL
Reactivity:Human
Clone Number:ARC54647
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MGAP TLPP AWQP FLKD HRIS TFKN WPFL EGCA CTPE RMAE AGFI HCPT ENEP DLAQ CFFC FKEL EGWE PDDD PIEE HKKH SSGC AFLS VKKQ FEEL TLGE FLKL DRER AKNK IAKE TNNK KKEF EETA EKVR RAIE QLAA MD
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:API4, EPR-1, Survivin
Positive Sample:293F, Jurkat, HeLa
Cellular Localization:Chromosome, Cytoplasm, Midbody, Nucleus, Centromere, Cytoskeleton, Kinetochore, Spindle.
Calculated MW:16kDa
Observed MW:16kDa

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Purification MethodAffinity purification
Gene ID332
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using Survivin Rabbit mAb (CAB22034) at1:2000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 90s.
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