The Sarm1 Monoclonal Antibody (CAB23440) is a high-quality antibody developed for reliable detection and analysis of target proteins. SARM1 is a NAD+ nucleosidase located in mitochondria and dendrites that plays a key role in NAD catabolism and neuron death regulation, acting as a critical executioner of Wallerian axon degeneration following injury. It is also involved in the regulation of apoptosis, dendrite morphogenesis, and the metabolic stress response.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
Sarm1 Monoclonal Antibody
SKU:
CAB23440
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
AMC0559
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Enables NAD+ nucleosidase activity. Involved in NAD catabolic process; positive regulation of neuron death; and regulation of dendrite morphogenesis. Acts upstream of or within regulation of apoptotic process and response to glucose. Located in several cellular components, including dendrite; microtubule; and mitochondrion. Is extrinsic component of mitochondrial outer membrane. Is expressed in immune system; nervous system; neural retina; and tongue. Orthologous to human SARM1 (sterile alpha and TIR motif containing 1).
Purification Method
Affinity purification
Gene ID
237868
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using Sarm1 Mouse mAb (CAB23440) at 1:8000 dilution. Secondary antibody: HRP-conjugated Goat anti-Mouse IgG (H+L) (CABS003) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 60s.
