Glucocorticoid Receptor Rabbit Polyclonal Antibody (CAB13667)

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SKU:
CAB13667
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
Reactivity:
Human, Mouse
Synonyms:
GR, GCR, GRL, GCCR, GCRST, Glucocorticoid Receptor
Research Use:
Cell Death
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Description

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Glucocorticoid Receptor Antibody (CAB13667)

The Glucocorticoid Receptor Antibody (CAB13667) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to NR3C1, this antibody enables detection and analysis of the protein in various cell types, allowing for deeper insights into its role in mediating glucocorticoid signaling pathways.The glucocorticoid receptor plays a crucial role in modulating immune and inflammatory responses, making it a key target for studies in immunology, endocrinology, and cancer research.

This antibody is validated for use in WB, IHC-P, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse samples.

Product Name:Glucocorticoid Receptor Antibody
SKU:CAB13667
Size:20μL, 100μL
Reactivity:Human, Mouse
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MDSK ESLT PGRE ENPS SVLA QERG DVMD FYKT LRGG ATVK VSAS SPSL AVAS QSDS KQRR LLVD FPKG SVSN AQQP DLSK AVSL SMGL YMGE TETK VMGN DLGF PQQG QISL SSGE TDLK LLEE SIAN LNRS TSVP ENPK SSAS TAVS AAPT EKEF PKTH SDVS SEQQ HLKG QTGT NGGN VKLY TTDQ STFD ILQD LEFS SGSP GKET NESP WRSD LLID ENCL LSPL AGED DSFL LEGN SNED CKPL ILPD TKPK IKDN GDLV LSSP SNVT LPQV KTEK
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:1000
IHC-P1:50 - 1:200
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:GR, GCR, GRL, GCCR, GCRST, Glucocorticoid Receptor
Positive Sample:HeLa, Mouse skeletal muscle
Cellular Localization:Cytoplasm, Mitochondrion, Nucleus, Nucleus.
Calculated MW:86kDa
Observed MW:90-100kDa

This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).

Purification MethodAffinity purification
Gene ID2908
RRIDAB_2760528
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageImmunofluorescence analysis of U2OS cells using Glucocorticoid Receptor Rabbit pAb (CAB13667) at dilution of 1:100. Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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