UniProt Protein Function: | MMP16: Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells. Belongs to the peptidase M10A family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.4.24.-; Membrane protein, integral; Protease Chromosomal Location of Human Ortholog: 8q21.3 Cellular Component: Golgi lumen; integral to plasma membrane; plasma membrane Molecular Function:enzyme activator activity; metalloendopeptidase activity; zinc ion binding Biological Process: extracellular matrix disassembly; protein metabolic process; protein processing; proteolysis |
NCBI Summary: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010] |
UniProt Code: | P51512 |
NCBI GenInfo Identifier: | 3041669 |
NCBI Gene ID: | 4325 |
NCBI Accession: | P51512.2 |
UniProt Secondary Accession: | P51512,Q14824, Q52H48, B2RAN7, |
UniProt Related Accession: | P51512 |
Molecular Weight: | Observed MW: 60kDaCalculated MW: 52kDa/69kDa |
NCBI Full Name: | Matrix metalloproteinase-16 |
NCBI Synonym Full Names: | matrix metallopeptidase 16 |
NCBI Official Symbol: | MMP16 |
NCBI Official Synonym Symbols: | MMP-X2; C8orf57; MT-MMP2; MT-MMP3; MT3-MMP |
NCBI Protein Information: | matrix metalloproteinase-16 |
UniProt Protein Name: | Matrix metalloproteinase-16 |
UniProt Synonym Protein Names: | MMP-X2; Membrane-type matrix metalloproteinase 3; MT-MMP 3; MTMMP3; Membrane-type-3 matrix metalloproteinase; MT3-MMP; MT3MMP |
Protein Family: | Matrix metalloproteinase |
UniProt Gene Name: | MMP16 |