[KO Validated] PARP1 Rabbit Monoclonal Antibody (CAB19596)

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SKU:
CAB19596
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
Antibody Type:
Monoclonal Antibody
Reactivity:
Human, Mouse, Rat
Synonyms:
PARP, PARS, PPOL, ADPRT, ARTD1, ADPRT1, PARP-1, ADPRT 1, pADPRT-1, Poly-PARP, PARP1
Research Use:
Epigenetics and Nuclear Signaling
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Description

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[KO Validated] PARP1 Monoclonal Antibody (CAB19596)

The [KO Validated] PARP1 Monoclonal Antibody (CAB19596) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, derived from rabbits, is highly specific and has been validated for use in assays including Western blotting, immunoprecipitation, and immunofluorescence microscopy.PARP plays a key role in DNA damage repair mechanisms, making it an important target for cancer therapeutics and research. The CAB19596 antibody binds specifically to PARP protein, allowing for precise detection and analysis in a variety of cell types and experimental settings.

This antibody is validated for use in IHC-P, IF/ICC, ELISA, IF-P applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:[KO Validated] PARP1 Monoclonal Antibody
SKU:CAB19596
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Clone Number:ARC0075
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:KLSK RQIQ AAYS ILSE VQQA VSQG SSDS QILD LSNR FYTL IPHD FGMK KPPL LNNA DSVQ AKVE MLDN LLDI EVAY SLLR GGSD DSSK DPID VNYE KLKT D
Tested Applications:IHC-P IF/ICC ELISA IF-P
Recommended Dilution:
IF/ICC1:50 - 1:200
IF-P1:50 - 1:200
IHC-P1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:PARP, PARS, PPOL, ADPRT, ARTD1, ADPRT1, PARP-1, ADPRT 1, pADPRT-1, Poly-PARP, PARP1
Cellular Localization:Nucleus, Nucleolus.
Calculated MW:113kDa
Observed MW:Refertofigures

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Purification MethodAffinity purification
Gene ID142
RRIDAB_2862689
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human colon using PARP1 Rabbit mAb (CAB19596) at dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human liver cancer using PARP1 Rabbit mAb (CAB19596) at dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human spleen using PARP1 Rabbit mAb (CAB19596) at dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human tonsil using PARP1 Rabbit mAb (CAB19596) at dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
Product ImageImmunohistochemistry analysis of paraffin-embedded Mouse colon using PARP1 Rabbit mAb (CAB19596) at dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
Product ImageImmunohistochemistry analysis of paraffin-embedded Mouse kidney using PARP1 Rabbit mAb (CAB19596) at dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
Product ImageImmunohistochemistry analysis of paraffin-embedded Rat brain using PARP1 Rabbit mAb (CAB19596) at dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
Product ImageImmunohistochemistry analysis of paraffin-embedded Rat heart using PARP1 Rabbit mAb (CAB19596) at dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
Product ImageImmunofluorescence analysis of HeLa cells using PARP1 Rabbit mAb (CAB19596) at dilution of 1:50 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
Product ImageImmunofluorescence analysis of paraffin-embedded human lung using PARP1 Rabbit mAb (CAB19596) at dilution of 1:50 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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