The CNPase Antibody (CAB1018) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced through immunization of rabbits, exhibits high specificity and sensitivity in detecting CNP in human samples, making it ideal for use in various research applications such as Western blotting.CNP, also known as C-type natriuretic peptide, is a peptide hormone with diverse functions in the body, including regulation of blood pressure, vascular tone, and cell growth. Dysregulation of CNP signaling has been associated with cardiovascular diseases, neurological disorders, and certain cancers, making it a target of interest for therapeutic interventions.
This antibody is validated for use in WB, ELISA, IF-P applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
CNPase Antibody
SKU:
CAB1018
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
CNP1, HLD20, CNPase
Positive Sample:
HepG2, 293T, Rat brain, Mouse brain, Hep G2, A-375
Cellular Localization:
Lipid-Anchor, Melanosome, Membrane.
Calculated MW:
48kDa
Observed MW:
48kDa
Predicted to enable 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity. Involved in substantia nigra development. Located in several cellular components, including extracellular space; microtubule; and plasma membrane. Implicated in hypomyelinating leukodystrophy 20; multiple sclerosis; and schizophrenia. Biomarker of alcoholic liver cirrhosis; multiple sclerosis; and restless legs syndrome.
Purification Method
Affinity purification
Gene ID
1267
RRID
AB_2757702
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using CNPase Rabbit pAb (CAB1018) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates / proteins: 25 μg per lane. Blocking buffer: 3 % nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s.
Immunofluorescence analysis of paraffin-embedded rat brain using CNPasease Rabbit pAb (CAB1018) at dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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