The CD138/Syndecan-1 Monoclonal Antibody (CAB23248) is a high-quality antibody developed for reliable detection and analysis of target proteins. This monoclonal antibody, produced through hybridoma technology, has high specificity for human CD138 and has been validated for use in various applications, including immunohistochemistry and flow cytometry.CD138, a member of the syndecan family, plays a crucial role in cell-matrix interactions and is often overexpressed in certain cancers, particularly multiple myeloma. By targeting CD138 with this monoclonal antibody, researchers can investigate its role in cancer progression, metastasis, and potential therapeutic interventions.
This antibody is validated for use in IHC-P, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
CD138/Syndecan-1 Monoclonal Antibody
SKU:
CAB23248
Size:
20μL, 100μL
Reactivity:
Human
Clone Number:
ARC60158
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Tested Applications:
IHC-PELISA
Recommended Dilution:
IHC-P
1:50 - 1:200
ELISA
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
SDC, CD138, SYND1, syndecan, CD138/Syndecan-1
Cellular Localization:
Membrane, Secreted, Single-Pass Type I Membrane Protein.
Calculated MW:
32kDa
Observed MW:
Refertofigures
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.
Purification Method
Affinity purification
Gene ID
6382
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Immunohistochemistry analysis of paraffin-embedded Human appendix using CD138/Syndecan-1 Rabbit mAb (CAB23248) at dilution of 1:100 (40x lens). High pressure antigen retrieval performed with 0.01M Tris/EDTA Buffer (pH 9.0) prior to IHC staining.
Immunohistochemistry analysis of paraffin-embedded Human cervix cancer using CD138/Syndecan-1 Rabbit mAb (CAB23248) at dilution of 1:100 (40x lens). High pressure antigen retrieval performed with 0.01M Tris/EDTA Buffer (pH 9.0) prior to IHC staining.
Immunohistochemistry analysis of paraffin-embedded Human lung adenocarcinoma using CD138/Syndecan-1 Rabbit mAb (CAB23248) at dilution of 1:100 (40x lens). High pressure antigen retrieval performed with 0.01M Tris/EDTA Buffer (pH 9.0) prior to IHC staining.
