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  • #免疫学 #T細胞

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抗原提示細胞(APC)と癌免疫療法

抗原提示細胞(APC)と癌免疫療法

MHC クラス I 分子の多様性と機能に焦点を当て、適応免疫における抗原提示の重要な役割とそれが癌免疫療法に与える影響を探ります。重要なポイントMHC クラス I による抗原提示は、適応免疫の鍵となります。特殊な細胞である抗原提示細胞 (APC) が T 細胞に抗原を提示します。MHC-I 分子の多型により、多様な抗原提示が可能になります。がん免疫療法では、抗原提示を利用して腫瘍細胞を標的にします。抗原提示とは?私たちの免疫システムには、病原体から身を守るためのさまざまなメカニズムがあり、適応免疫は重要な要素です。適応免疫により、免疫システムは特定の病原体に対して専門的で標的を絞った免疫反応を開始できます。このプロセスに関係する重要な経路の 1 つは、1987 年に Bjorkman らによって発見された MHC クラス I 抗原提示経路です。複雑に聞こえるかもしれませんが、基本的な概念は非常に単純です。細胞内のタンパク質は、リサイクルを促進するために絶えず分解されます。興味深いことに、これらの分解産物の一部は、通常 8 ~ 11 個のアミノ酸で構成される短 …
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31st Dec 2024 Sana Riaz
T 細胞の免疫表現型検査 - ガイド

T 細胞の免疫表現型検査 - ガイド

導入T リンパ球は、免疫系で重要な役割を果たす白血球の一種です。 T 細胞にはさまざまな種類があり、その機能を研究するにはそれらを正確に区別できることが重要です。免疫表現型検査は、これらのさまざまな種類の T リンパ球を特定し、分類するプロセスです。このガイドでは、T 細胞を識別するために使用されるさまざまなマーカーと、フローサイトメトリーを使用して T 細胞を分類する方法について説明します。また、さまざまなヘルパー T 細胞サブセットとその活性化マーカーについても見ていきます。免疫表現型検査の基本を理解することで、免疫関連疾患を効果的に診断し、治療できるようになります。重要なポイントT 細胞は多様で、CD4+ ヘルパー、CD8+ 細胞傷害性 T 細胞、制御性 T 細胞などのサブセットがあり、それぞれが独自の機能を持っています。CD45、CD25、CD69 などの表面マーカーは、T 細胞の状態と活性化レベルを区別します。Th0、Th17、Treg などのヘルパー T 細胞は、CD25、RORγt、Foxp3 などの特異的なマーカーによって識別されます。フロー …
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28th Nov 2024 Sana Riaz
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