Anti-VPS24 Antibody (CAB0941)

(No reviews yet) Write a Review
SKU:
CAB0941
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CGI-149
Synonyms:
NEDF
Synonyms:
VPS24
€0.00
Frequently bought together:

Description

I抗体名:VPS24 Rabbit mAb
抗体コード:CAB0941
サイズ:20uL, 50uL, 100uL
同義語:CGI-149, NEDF, VPS24
申し込み:WB
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:A synthesized peptide derived from human VPS24
申し込み:WB
推奨される希釈:WB 1:500 - 1:2000
反応性:Human, Mouse, Rat
ポジティブサンプル:293T, A-549, SH-SY5Y, Mouse brain, Rat brain
免疫原:A synthesized peptide derived from human VPS24
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:51652
Uniprot:Q9Y3E7
計算された分子量:29kDa
観察された分子量:29kDa
UniProt Protein Function:VPS24: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress- mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells. Belongs to the SNF7 family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Vesicle

Chromosomal Location of Human Ortholog: 2p11.2

Cellular Component: cytoplasmic vesicle; cytosol; intracellular; late endosome; plasma membrane

Molecular Function:phosphatidylcholine binding; protein binding; protein homodimerization activity

Biological Process: cell separation during cytokinesis; endosome transport; macroautophagy; mitotic metaphase plate congression; nuclear organization and biogenesis; protein heterooligomerization; protein polymerization; regulation of viral reproduction; viral infectious cycle

NCBI Summary:This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene. [provided by RefSeq, Nov 2010]
UniProt Code:Q9Y3E7
NCBI GenInfo Identifier:73917763
NCBI Gene ID:51652
NCBI Accession:Q9Y3E7.3
UniProt Secondary Accession:Q9Y3E7,Q3ZTS9, Q53S71, Q53SU5, Q9NZ51, A8K3W0, B4DG34 B8ZZM0, B8ZZX5,
UniProt Related Accession:Q9Y3E7
Molecular Weight:25kDa
NCBI Full Name:Charged multivesicular body protein 3
NCBI Synonym Full Names:charged multivesicular body protein 3
NCBI Official Symbol:CHMP3  
NCBI Official Synonym Symbols:NEDF; VPS24; CGI-149  
NCBI Protein Information:charged multivesicular body protein 3
UniProt Protein Name:Charged multivesicular body protein 3
UniProt Synonym Protein Names:Chromatin-modifying protein 3; Neuroendocrine differentiation factor; Vacuolar protein sorting-associated protein 24; hVps24
Protein Family:Vacuolar protein sorting-associated protein
UniProt Gene Name:CHMP3  
View AllClose

View AllClose

Related Products