Anti-VGLUT2 Antibody [N29/29 (Formerly sold as S29-29)]

VGLUT2 Antibody [N29/29 (Formerly sold as S29-29)]

VGLUT2 Antibody [N29/29 (Formerly sold as S29-29)] is a mouse monoclonal antibody directed against VGLUT2, offered by Assay Genie for research applications. Reported applications include WB, IHC and ICC/IF. Reported reactivity: Human, Mouse and Rat. Supplied as IgG1, purified by Protein G.

Vesicular Glutamate Transporter 2 (VGLUT2), encoded by SLC17A6, is an ATP-dependent, chloride-sensitive transporter essential for loading glutamate into synaptic vesicles. Alongside VGLUT1 (BNPI) and VGLUT3, VGLUT2 plays a pivotal role in excitatory neurotransmission. Its expression is regionally distinct and complementary to VGLUT1: while VGLUT1 predominates in telencephalic regions, VGLUT2 is highly expressed in the diencephalon and lower brainstem—areas critical for autonomic control, sensory integration, and motor coordination. VGLUT2 is also expressed in rat pinealocytes and pancreatic α and β cells, where it responds to glucose levels, suggesting a broader role in neuroendocrine signaling. This transporter is particularly relevant in the context of neurodegenerative diseases, as its dysregulation has been implicated in conditions such as Parkinson’s disease, amyotrophic lateral sclerosis (ALS), and Huntington’s disease. Its involvement in glutamate homeostasis and excitotoxicity positions VGLUT2 as a key molecular target for understanding disease mechanisms and developing therapeutic interventions. Although VGLUT3 shares approximately 72% sequence homology with VGLUT2 and VGLUT1, each isoform exhibits distinct spatial and functional profiles. VGLUT2’s unique distribution and regulatory mechanisms make it a critical focus in neuroscience research, particularly in studies of synaptic plasticity, circuit dysfunction, and neurodegeneration. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.