Anti-SF3B1 Antibody (CAB9737)

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SKU:
CAB9737
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
Hsh155
Synonyms:
MDS
Synonyms:
PRP10
Synonyms:
PRPF10
Synonyms:
SAP155
Synonyms:
SF3b155
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Description

抗体名:SF3B1 Rabbit mAb
抗体コード:CAB9737
サイズ:20uL, 50uL, 100uL
同義語:Hsh155, MDS, PRP10, PRPF10, SAP155, SF3b155
申し込み:WB, IHC, IF
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:A synthesized peptide derived from human SF3B1
申し込み:WB, IHC, IF
推奨される希釈:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
反応性:Human, Mouse, Rat
ポジティブサンプル:HeLa, NIH/3T3, Jurkat, Mouse brain
免疫原:A synthesized peptide derived from human SF3B1
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:23451
Uniprot:O75533
計算された分子量:155kDa
観察された分子量:146KDa
UniProt Protein Function:SF3B1: subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (bps) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. Phosphorylated during the splicing catalytic steps.
UniProt Protein Details:

Protein type:RNA-binding; Spliceosome; RNA splicing

Chromosomal Location of Human Ortholog: 2q33.1

Cellular Component: nucleoplasm; nucleus; snRNP U2; U12-dependent spliceosome

Molecular Function:mRNA binding; protein binding

Biological Process: nuclear mRNA splicing, via spliceosome; positive regulation of gene expression, epigenetic; spliceosome assembly

Disease: Myelodysplastic Syndrome

NCBI Summary:This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:O75533
NCBI GenInfo Identifier:269849656
NCBI Gene ID:23451
NCBI Accession:O75533.3
UniProt Secondary Accession:O75533,E9PCH3,
UniProt Related Accession:O75533
Molecular Weight:16,020 Da
NCBI Full Name:Splicing factor 3B subunit 1
NCBI Synonym Full Names:splicing factor 3b subunit 1
NCBI Official Symbol:SF3B1  
NCBI Official Synonym Symbols:MDS; PRP10; Hsh155; PRPF10; SAP155; SF3b155  
NCBI Protein Information:splicing factor 3B subunit 1
UniProt Protein Name:Splicing factor 3B subunit 1
UniProt Synonym Protein Names:Pre-mRNA-splicing factor SF3b 155 kDa subunit; SF3b155; Spliceosome-associated protein 155; SAP 155
Protein Family:Splicing factor
UniProt Gene Name:SF3B1  
UniProt Entry Name:SF3B1_HUMAN
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