Anti-SAE1 Antibody (CAB9960)
- SKU:
- CAB9960
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-SAE1 Antibody |
抗体コード: | CAB9960 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-346 of human SAE1 (NP_005491.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | HeLa, B cells, K-562, HT-29, LO2, NIH/3T3 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-346 of human SAE1 (NP_005491.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MVEK EEAG GGIS EEEA AQYD RQIR LWGL EAQK RLRA SRVL LVGL KGLG AEIA KNLI LAGV KGLT MLDH EQVT PEDP GAQF LIRT GSVG RNRA EASL ERAQ NLNP MVDV KVDT EDIE KKPE SFFT QFDA VCLT CCSR DVIV KVDQ ICHK NSIK FFTG DVFG YHGY TFAN LGEH EFVE EKTK VAKV SQGV EDGP DTKR AKLD SSET TMVK KKVV FCPV KEAL EVDW SSEK AKAA LKRT TSDY FLLQ VLLK FRTD KGRD PSSD TYEE DSEL LLQI RNDV LDSL GISP DLLP EDFV RYCF SEMA PVCA VVGG ILAQ EIVK ALSQ RDPP HNNF FFFD GMKG NGIV ECLG PK |
遺伝子ID: | 10055 |
Uniprot: | Q9UBE0 |
セルラーロケーション: | Nucleus |
計算された分子量: | 29kDa/33kDa/38kDa |
観察された分子量: | 38kDa |
同義語: | SAE1, AOS1, HSPC140, SUA1, UBLE1A |
バックグラウンド: |
UniProt Protein Function: | UBLE1A: The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. |
UniProt Protein Details: | Protein type:Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.19 Chromosomal Location of Human Ortholog: 19q13.32 Cellular Component: cytosol; nucleoplasm; nucleus Molecular Function:ATP-dependent protein binding; enzyme activator activity; protein binding; protein C-terminus binding; protein heterodimerization activity; SUMO activating enzyme activity; ubiquitin activating enzyme activity Biological Process: protein sumoylation; protein ubiquitination; regulation of mitotic cell cycle |
NCBI Summary: | Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010] |
UniProt Code: | Q9UBE0 |
NCBI GenInfo Identifier: | 42559897 |
NCBI Gene ID: | 10055 |
NCBI Accession: | Q9UBE0.1 |
UniProt Secondary Accession: | Q9UBE0,O95717, Q9P020, B2RDP5, B3KMQ2, F5GXX7, G3XAK6 |
UniProt Related Accession: | Q9UBE0 |
Molecular Weight: | 33,063 Da |
NCBI Full Name: | SUMO-activating enzyme subunit 1 |
NCBI Synonym Full Names: | SUMO1 activating enzyme subunit 1 |
NCBI Official Symbol: | SAE1 |
NCBI Official Synonym Symbols: | AOS1; SUA1; UBLE1A; HSPC140 |
NCBI Protein Information: | SUMO-activating enzyme subunit 1 |
UniProt Protein Name: | SUMO-activating enzyme subunit 1 |
UniProt Synonym Protein Names: | Ubiquitin-like 1-activating enzyme E1A |
Protein Family: | SUMO-activating enzyme |
UniProt Gene Name: | SAE1 |
UniProt Entry Name: | SAE1_HUMAN |
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