Anti-SAE1 Antibody (CAB0891)
- SKU:
- CAB0891
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- AOS1
- Synonyms:
- HSPC140
- Synonyms:
- SUA1
- Synonyms:
- UBLE1A
Frequently bought together:
Description
抗体名: | SAE1 Rabbit mAb |
抗体コード: | CAB0891 |
サイズ: | 20uL, 50uL, 100uL |
同義語: | AOS1, HSPC140, SUA1, UBLE1A |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthesized peptide derived from human SAE1 |
申し込み: | WB |
推奨される希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | 293T, MCF7, DU145, Mouse testis, Mouse thymus, Rat testis |
免疫原: | A synthesized peptide derived from human SAE1 |
精製方法: | Affinity purification |
保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 10055 |
Uniprot: | Q9UBE0 |
計算された分子量: | 38kDa |
観察された分子量: | 40kDa |
UniProt Protein Function: | UBLE1A: The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. |
UniProt Protein Details: | Protein type:Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.19 Chromosomal Location of Human Ortholog: 19q13.32 Cellular Component: cytosol; nucleoplasm; nucleus Molecular Function:ATP-dependent protein binding; enzyme activator activity; protein binding; protein C-terminus binding; protein heterodimerization activity; SUMO activating enzyme activity; ubiquitin activating enzyme activity Biological Process: protein sumoylation; protein ubiquitination; regulation of mitotic cell cycle |
NCBI Summary: | Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010] |
UniProt Code: | Q9UBE0 |
NCBI GenInfo Identifier: | 42559897 |
NCBI Gene ID: | 10055 |
NCBI Accession: | Q9UBE0.1 |
UniProt Secondary Accession: | Q9UBE0,O95717, Q9P020, B2RDP5, B3KMQ2, F5GXX7, G3XAK6 |
UniProt Related Accession: | Q9UBE0 |
Molecular Weight: | 33,063 Da |
NCBI Full Name: | SUMO-activating enzyme subunit 1 |
NCBI Synonym Full Names: | SUMO1 activating enzyme subunit 1 |
NCBI Official Symbol: | SAE1 |
NCBI Official Synonym Symbols: | AOS1; SUA1; UBLE1A; HSPC140 |
NCBI Protein Information: | SUMO-activating enzyme subunit 1 |
UniProt Protein Name: | SUMO-activating enzyme subunit 1 |
UniProt Synonym Protein Names: | Ubiquitin-like 1-activating enzyme E1A |
Protein Family: | SUMO-activating enzyme |
UniProt Gene Name: | SAE1 |
UniProt Entry Name: | SAE1_HUMAN |