Anti-Phospho-PLN-S16/T17 Antibody (CABP0956)

(No reviews yet) Write a Review
SKU:
CABP0956
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CMD1P
Synonyms:
CMH18
Synonyms:
PLB
Synonyms:
PLN
€0.00
Frequently bought together:

Description

抗体名:Phospho-PLN-S16/T17 Rabbit pAb
抗体コード:CABP0956
サイズ:20uL, 50uL, 100uL
同義語:CMD1P, CMH18, PLB, PLN
申し込み:WB
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:A synthetic phosphorylated peptide around of human Phospho-PLN-S16/T17.
申し込み:WB
推奨される希釈:WB 1:500 - 1:2000
反応性:Human, Mouse, Rat
ポジティブサンプル:HeLa, C6
免疫原:A synthetic phosphorylated peptide around of human Phospho-PLN-S16/T17.
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:5350
Uniprot:P26678
計算された分子量:6kDa
観察された分子量:13kDa/17KDa
UniProt Protein Function:PLB: a heart protein postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum. A major substrate for the cAMP-dependent protein kinase. An inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. A key regulator of cardiac diastolic function. Mutations are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure.
UniProt Protein Details:

Protein type:Membrane protein, integral; Inhibitor

Chromosomal Location of Human Ortholog: 6q22.1

Cellular Component: endoplasmic reticulum; membrane; mitochondrion; perinuclear region of cytoplasm; sarcoplasmic reticulum membrane

Molecular Function:ATPase binding; ATPase inhibitor activity; enzyme inhibitor activity; identical protein binding; protein binding

Biological Process: cytosolic calcium ion homeostasis; negative regulation of ATPase activity; negative regulation of calcium ion transport; negative regulation of catalytic activity; negative regulation of heart rate; regulation of calcium ion transport; regulation of heart contraction; regulation of the force of heart contraction

Disease: Cardiomyopathy, Dilated, 1p; Cardiomyopathy, Familial Hypertrophic, 18

NCBI Summary:The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016]
UniProt Code:P26678
NCBI GenInfo Identifier:130774
NCBI Gene ID:5350
NCBI Accession:P26678.1
UniProt Secondary Accession:P26678,P61016, P61015, P61013, P61014, A4IFH6,
UniProt Related Accession:P26678
Molecular Weight:6,109 Da
NCBI Full Name:Cardiac phospholamban
NCBI Synonym Full Names:phospholamban
NCBI Official Symbol:PLN  
NCBI Official Synonym Symbols:PLB; CMD1P; CMH18  
NCBI Protein Information:cardiac phospholamban
UniProt Protein Name:Cardiac phospholamban
Protein Family:Cardiac phospholamban
UniProt Gene Name:PLN  
UniProt Entry Name:PPLA_HUMAN
View AllClose

View AllClose

Related Products