Anti-Phospho-Beclin 1-Ser90 Antibody (CABP1254)

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SKU:
CABP1254
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ATG6
Synonyms:
VPS30
Synonyms:
beclin1
Synonyms:
Beclin 1
Synonyms:
BECN1
Synonyms:
beclin-1
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Description

抗体名:Phospho-Beclin 1-Ser90 Rabbit pAb
抗体コード:CABP1254
サイズ:50uL, 100uL
同義語:ATG6, VPS30, beclin1, Beclin 1, BECN1, beclin-1
申し込み:WB
反応性:Human, Mouse
宿主種:Rabbit
免疫原:A phospho specific peptide corresponding to residues surrounding Ser90 of human Beclin 1
申し込み:WB
推奨される希釈:WB 1:500 - 1:2000
反応性:Human, Mouse
ポジティブサンプル:HeLa, NIH/3T3
免疫原:A phospho specific peptide corresponding to residues surrounding Ser90 of human Beclin 1
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:8678
Uniprot:Q14457
セルラーロケーション:Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum membrane, Endosome, Endosome membrane, Golgi apparatus, Mitochondrion, Mitochondrion membrane, Nucleus, Peripheral membrane protein, autophagosome, trans-Golgi network membrane
計算された分子量:52kDa
観察された分子量:60KDa
UniProt Protein Function:beclin 1: an essential autophagy protein that has been linked to multiple processes including tumor suppression, protection against some cardiac and neurological degenerative diseases, and lifespan extension. A ubiquitous protein of the beclin family. Is part of the class III PI3K complex that induces autophagy. Expressed at elevated levels in dendrites and cell bodies of cerebellar Purkinje cells. Interacts with the anti-apoptotic protein Bcl-2, which inhibits autophagy when it is present in the endoplasmic reticulum. The dissociation of ATG6 from Bcl-2 is essential for its autophagic activity. Interacts with PITC and GluR-delta2. Probably forms a complex with AMBRA1 and PIK3C3. Plays a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.
UniProt Protein Details:

Protein type:Adaptor/scaffold; Autophagy; Membrane protein, peripheral

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: extrinsic to membrane; mitochondrion; endoplasmic reticulum; cytoplasmic membrane-bound vesicle; dendrite; phagocytic vesicle; trans-Golgi network; nucleus; endosome

Molecular Function:protein binding; phosphoinositide 3-kinase binding

Biological Process: response to drug; viral reproduction; late endosome to vacuole transport; cytokinesis; CVT pathway; cellular response to nitrogen starvation; negative regulation of cell proliferation; response to vitamin E; lysosome organization and biogenesis; regulation of catalytic activity; beta-amyloid metabolic process; mitochondrion degradation; response to hypoxia; cellular defense response; neuron development; defense response to virus; positive regulation of macroautophagy; positive regulation of autophagy; negative regulation of apoptosis; autophagic vacuole formation

NCBI Summary:Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 [PubMed 19270693]).[supplied by OMIM, Jul 2010]
UniProt Code:Q14457
NCBI GenInfo Identifier:4680381
NCBI Gene ID:8678
NCBI Accession:AAD27650.1
UniProt Secondary Accession:Q14457,O75595, Q9UNA8,
UniProt Related Accession:Q14457
Molecular Weight:51,896 Da
NCBI Full Name:beclin 1
NCBI Synonym Full Names:beclin 1, autophagy related
NCBI Official Symbol:BECN1  
NCBI Official Synonym Symbols:ATG6; VPS30; beclin1  
NCBI Protein Information:beclin-1; ATG6 autophagy related 6 homolog; coiled-coil myosin-like BCL2-interacting protein; beclin 1 (coiled-coil, moesin-like BCL2 interacting protein); beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)
UniProt Protein Name:Beclin-1
UniProt Synonym Protein Names:Coiled-coil myosin-like BCL2-interacting protein; Protein GT197
Protein Family:Beclin
UniProt Gene Name:BECN1  
UniProt Entry Name:BECN1_HUMAN
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