Anti-PEN2/PSENEN Antibody (CAB8678)

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SKU:
CAB8678
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MDS033
Synonyms:
MSTP064
Synonyms:
PEN-2
Synonyms:
PEN2
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Description

I抗体名:PEN2/PSENEN Rabbit mAb
抗体コード:CAB8678
サイズ:20uL, 50uL, 100uL
同義語:MDS033, MSTP064, PEN-2, PEN2
申し込み:WB, IF
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:A synthesized peptide derived from human PEN2/PSENEN
申し込み:WB, IF
推奨される希釈:WB 1:500 - 1:2000 IF 1:50 - 1:200
反応性:Human, Mouse, Rat
ポジティブサンプル:293T, A-549, SH-SY5Y, Mouse kidney, Rat lung
免疫原:A synthesized peptide derived from human PEN2/PSENEN
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:55851
Uniprot:Q9NZ42
計算された分子量:13kDa
観察された分子量:14kDa
UniProt Protein Function:PSENEN: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PSENEN/PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist. Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Belongs to the PEN-2 family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.12

Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; endoplasmic reticulum; integral to plasma membrane; plasma membrane

Molecular Function:protein binding

Biological Process: positive regulation of catalytic activity; axon guidance; Notch signaling pathway; amyloid precursor protein catabolic process; membrane protein intracellular domain proteolysis; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; membrane protein ectodomain proteolysis; ephrin receptor signaling pathway; Notch receptor processing; protein processing

Disease: Acne Inversa, Familial, 2

NCBI Summary:Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Code:Q9NZ42
NCBI GenInfo Identifier:28144920
NCBI Gene ID:55851
NCBI Accession:NP_758844
UniProt Related Accession:Q9NZ42
Molecular Weight:~ 12kDa
NCBI Full Name:gamma-secretase subunit PEN-2
NCBI Synonym Full Names:presenilin enhancer, gamma-secretase subunit
NCBI Official Symbol:PSENEN  
NCBI Official Synonym Symbols:PEN2; PEN-2; MDS033; ACNINV2; MSTP064  
NCBI Protein Information:gamma-secretase subunit PEN-2
UniProt Protein Name:Gamma-secretase subunit PEN-2
UniProt Synonym Protein Names:Presenilin enhancer protein 2
UniProt Gene Name:PSENEN  
UniProt Entry Name:PEN2_HUMAN
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