Anti-Nav1.7 Antibody [N68/6 (Formerly sold as S68-6)]

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SKU:
STMA00088
SKU:
STMA00088
Antibody Type:
Monoclonal
Applications:
WB
Applications:
IHC
Applications:
ICC/IF
Applications:
IP
Applications:
AM
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Reactivity:
Hamster
Host Species:
Mouse
Isotype:
IgG1
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Description

Nav1.7 Antibody [N68/6 (Formerly sold as S68-6)]

Nav1.7 Antibody [N68/6 (Formerly sold as S68-6)] is a mouse monoclonal antibody directed against Nav1.7, offered by Assay Genie for research applications. Reported applications include WB, IHC, ICC/IF, IP and AM. Reported reactivity: Human, Mouse, Rat and Hamster. Supplied as IgG1, purified by Protein G.

Nav1.7 is a voltage-gated sodium channel encoded by the SCN9A gene and is predominantly expressed in peripheral sensory neurons. It plays a pivotal role in pain perception by amplifying subthreshold stimuli and facilitating action potential initiation. Loss-of-function mutations in Nav1.7 result in congenital insensitivity to pain, while gain-of-function mutations are associated with chronic pain syndromes. Importantly, Nav1.7 is not expressed in cardiac or central neurons, making it an attractive target for pain therapeutics with minimal off-target effects. Although primarily studied in nociception, emerging research suggests that peripheral nerve dysfunction and chronic pain may contribute to neurodegenerative disease burden. Nav1.7 inhibitors are under investigation as next-generation analgesics with potential applications in neurodegenerative conditions involving neuropathic pain. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.

Product Name:Nav1.7 Antibody [N68/6 (Formerly sold as S68-6)]
Product SKU:STMA00088
Size:100 µg
Target:Nav1.7
Host Species:Mouse
Antibody Type:Monoclonal
Clone ID:N68/6 (Formerly sold as S68-6)
Research Areas:Neuroscience, Ion Channels, Sodium Channels, Voltage-Gated Sodium Channels, Cancer, Cell Signaling
Buffer:PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage & Shipping:Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:Liquid
Applications:WB, IHC, ICC/IF, IP, AM
Antibody Isotype:IgG1
Purification:Protein G Purified
Concentration:1 mg/ml
Reactivity:Human, Mouse, Rat, Hamster
Recommended Dilution:WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Specificity:Detects ~230kDa. No cross-reactivity against other Nav channels.
Guarantee:12 months from date of dispatch
Immunogen:Fusion protein amino acids 1751-1946 (C-terminus) of human Nav1.7
Immunogen Species:Human
Accession Number:NP_002968.1
Gene ID:1917-05-05 00:00:00
Swiss-Prot:Q15858
Cellular Localization:Membrane | Synapse
Alternative Names:Nav1.7, SCN9A, ETHA, hNE Na, NE NA, PN1, Voltage gated sodium channel subunit alpha Nav1, Peripheral sodium channel 1, Neuroendocrine sodium channel
References:1. Dray A. (2008) Br. J. Anaesth. 101(1): 48-58. 2. Dray A., Read S.J (2007) Arthritis Res. Ther. 9(3): 212. 3. Samuels M.E., teMorshe R.H., Lynch M.E., Drenth J.P. (2008) Mol Pain. 4: 21.
Note:For research use only.
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