Anti-MPO Antibody (CAB1374)
- SKU:
- CAB1374
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-MPO Antibody |
抗体コード: | CAB1374 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-310 of human MPO (NP_000241.1). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HL-60 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-310 of human MPO (NP_000241.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | APAV LGEV DTSL VLSS MEEA KQLV DKAY KERR ESIK QRLR SGSA SPME LLSY FKQP VAAT RTAV RAAD YLHV ALDL LERK LRSL WRRP FNVT DVLT PAQL NVLS KSSG CAYQ DVGV TCPE QDKY RTIT GMCN NRRS PTLG ASNR AFVR WLPA EYED GFSL PYGW TPGV KRNG FPVA LARA VSNE IVRF PTDQ LTPD QERS LMFM QWGQ LLDH DLDF TPEP AARA SFVT GVNC ETSC VQQP PCFP LKIP PNDP RIKN QADC I |
遺伝子ID: | 4353 |
Uniprot: | P05164 |
セルラーロケーション: | Lysosome |
計算された分子量: | 73kDa/83kDa/87kDa |
観察された分子量: | 60KDa |
同義語: | MPO |
バックグラウンド: | Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. |
UniProt Protein Function: | MPO: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain. Belongs to the peroxidase family. XPO subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 1.11.2.2; Oxidoreductase Chromosomal Location of Human Ortholog: 17q23.1 Cellular Component: extracellular space; azurophil granule; mitochondrion; lysosome; nucleus; secretory granule Molecular Function:heparin binding; peroxidase activity; metal ion binding; heme binding; chromatin binding Biological Process: respiratory burst during defense response; response to food; removal of superoxide radicals; response to mechanical stimulus; hydrogen peroxide catabolic process; defense response; response to yeast; response to lipopolysaccharide; response to oxidative stress; defense response to fungus; negative regulation of apoptosis; aging Disease: Myeloperoxidase Deficiency; Alzheimer Disease |
NCBI Summary: | Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008] |
UniProt Code: | P05164 |
NCBI GenInfo Identifier: | 129825 |
NCBI Gene ID: | 4353 |
NCBI Accession: | P05164.1 |
UniProt Secondary Accession: | P05164,Q14862, Q4PJH5, Q9UCL7, A1L4B8, |
UniProt Related Accession: | P05164 |
Molecular Weight: | 87,248 Da |
NCBI Full Name: | Myeloperoxidase |
NCBI Synonym Full Names: | myeloperoxidase |
NCBI Official Symbol: | MPO |
NCBI Protein Information: | myeloperoxidase |
UniProt Protein Name: | Myeloperoxidase |
Protein Family: | Myeloperoxidase |
UniProt Gene Name: | MPO |
UniProt Entry Name: | PERM_HUMAN |
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