Anti-Mitofusin 2 Antibody [N153/5 (Formerly sold as S153-5)]

Mitofusin 2 Antibody [N153/5 (Formerly sold as S153-5)]

Mitofusin 2 Antibody [N153/5 (Formerly sold as S153-5)] is a mouse monoclonal antibody directed against Mitofusin 2, offered by Assay Genie for research applications. Reported applications include WB, IHC and ICC/IF. Reported reactivity: Human, Mouse and Rat. Supplied as IgG2a, purified by Protein G.

Mitofusin 2 (Mfn2) is a mitochondrial membrane protein that regulates mitochondrial fusion, bioenergetics, and inter-organelle communication. It plays a vital role in maintaining mitochondrial integrity and function in neurons, which are highly dependent on energy metabolism. Loss or dysfunction of Mfn2 impairs mitochondrial dynamics, leading to fragmented mitochondria, disrupted membrane potential, and increased oxidative stress. These mitochondrial abnormalities are implicated in neurodegenerative diseases such as Charcot-Marie-Tooth disease type 2A, Alzheimer’s disease, and Parkinson’s disease. Mfn2 also modulates mitochondrial transport along axons and participates in mitophagy, the selective degradation of damaged mitochondria. Its role in regulating apoptosis and inflammation further underscores its importance in neuronal survival. Targeting Mfn2 to restore mitochondrial dynamics and function represents a promising strategy for mitigating neurodegenerative processes and enhancing neuronal resilience. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.