Anti-LGI1 Antibody (CAB19230)
- SKU:
- CAB19230
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- LGI1
- Synonyms:
- ADLTE
- Synonyms:
- ADPAEF
- Synonyms:
- ADPEAF
- Synonyms:
- EPITEMPIN
- Synonyms:
- EPT
- Synonyms:
- ETL1
- Synonyms:
- IB1099
- Synonyms:
- leucine rich glioma inactivated 1
Frequently bought together:
Description
I抗体名: | LGI1 Rabbit mAb |
抗体コード: | CAB19230 |
サイズ: | 20uL, 50uL, 100uL |
同義語: | LGI1, ADLTE, ADPAEF, ADPEAF, EPITEMPIN, EPT, ETL1, IB1099, leucine rich glioma inactivated 1 |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant protein of human LGI1 . |
申し込み: | WB |
推奨される希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Mouse brain, Rat brain |
免疫原: | Recombinant protein of human LGI1 . |
精製方法: | Affinity purification |
保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 9211 |
Uniprot: | O95970 |
セルラーロケーション: | Cell junction, Secreted, synapse |
計算された分子量: | 64kDa |
観察された分子量: | 64KDa |
UniProt Protein Function: | LGI1: Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival. Defects in LGI1 are the cause of epilepsy, familial temporal lobe, type 1 (ETL1). A focal form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe. Seizures are usually accompanied by sensory symptoms, most often auditory in nature. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 10q24 Cellular Component: extracellular space; extracellular region; synapse; cell junction Molecular Function:protein binding; receptor binding Biological Process: axon guidance; nervous system development; cell proliferation; positive regulation of cell growth; neurite development; protein homooligomerization; positive regulation of synaptic transmission Disease: Epilepsy, Familial Temporal Lobe, 1 |
NCBI Summary: | This gene is rearranged as a result of translocations in glioblastoma cell lines. The protein contains a hydrophobic segment representing a putative transmembrane domain with the amino terminus located outside the cell. It also contains leucine-rich repeats with conserved cysteine-rich flanking sequences. This gene is predominantly expressed in neural tissues and its expression is reduced in low grade brain tumors and significantly reduced or absent in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. [provided by RefSeq, Jul 2008] |
UniProt Code: | O95970 |
NCBI GenInfo Identifier: | 32469669 |
NCBI Gene ID: | 9211 |
NCBI Accession: | O95970.1 |
UniProt Secondary Accession: | O95970,Q5W001, Q5W002, Q8NI23, Q96LF5, A8K0Z1, B4E1S0 |
UniProt Related Accession: | O95970 |
Molecular Weight: | 557 |
NCBI Full Name: | Leucine-rich glioma-inactivated protein 1 |
NCBI Synonym Full Names: | leucine-rich, glioma inactivated 1 |
NCBI Official Symbol: | LGI1 |
NCBI Official Synonym Symbols: | EPT; ETL1; ADLTE; ADPAEF; ADPEAF; IB1099; EPITEMPIN |
NCBI Protein Information: | leucine-rich glioma-inactivated protein 1; epitempin-1 |
UniProt Protein Name: | Leucine-rich glioma-inactivated protein 1 |
UniProt Synonym Protein Names: | Epitempin-1 |
Protein Family: | Leucine-rich glioma-inactivated protein |
UniProt Gene Name: | LGI1 |
UniProt Entry Name: | LGI1_HUMAN |