Anti-Kir4.1 Antibody

Kir4.1 Antibody

Kir4.1 Antibody is a rabbit polyclonal antibody directed against Kir4.1, offered by Assay Genie for research applications. Reported applications include WB, ICC/IF and IHC. Reported reactivity: Human and Rat. Purified by Peptide Affinity.

Kir4.1, an inwardly rectifying potassium channel encoded by KCNJ10, plays a pivotal role in maintaining ion homeostasis and extracellular potassium buffering in the central nervous system (CNS). Predominantly expressed in astrocytes, Kir4.1 is essential for regulating neuronal excitability, synaptic transmission, and neurovascular coupling. Disruption of Kir4.1 function has been increasingly implicated in the pathogenesis of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Huntington’s disease, and multiple sclerosis (MS). Loss or dysfunction of Kir4.1 impairs astrocytic potassium clearance and glutamate uptake, leading to excitotoxicity, oxidative stress, and chronic neuroinflammation—key drivers of progressive neuronal damage. Moreover, Kir4.1 dysregulation has been associated with blood-brain barrier breakdown and altered astrocyte-neuron metabolic coupling, further exacerbating neurodegenerative cascades. Recent studies highlight Kir4.1 as a potential biomarker and therapeutic target in neurodegeneration. Modulating Kir4.1 activity may restore glial function, reduce excitotoxic burden, and enhance neuroprotection. Its involvement in both genetic and acquired neurological disorders underscores its translational relevance across diverse disease models. As neuroscience advances toward glia-centered therapeutic strategies, Kir4.1 stands at the intersection of ion channel physiology, neuroinflammation, and neurodegeneration—offering a promising avenue for intervention and biomarker development. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.