JAK1 Rabbit Monoclonal Antibody (CAB11963)

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SKU:
CAB11963
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Reactivity:
Human, Mouse, Rat
Synonyms:
JTK3, AIIDE, JAK1A, JAK1B, JAK1
Research Use:
Cell Biology
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Description

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JAK1 Monoclonal Antibody (CAB11963)

The JAK1 Monoclonal Antibody (CAB11963) is a high-quality antibody developed for reliable detection and analysis of target proteins. This polyclonal antibody, developed using advanced technology, exhibits high specificity and sensitivity for human samples, making it an ideal choice for Western blot applications.The JAK1 protein is essential for the activation of various cytokine receptors and subsequent signaling cascades, making it a critical target for understanding immune responses, inflammatory processes, and cell proliferation.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:JAK1 Monoclonal Antibody
SKU:CAB11963
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Clone Number:ARC0434
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:GTLM DYKD DEGT SEEK KIKV ILKV LDPS HRDI SLAF FEAA SMMR QVSH KHIV YLYG VCVR DVEN IMVE EFVE GGPL DLFM HRKS DVLT TPWK FKVA KQLA S
Tested Applications:WB ELISA
Recommended Dilution:
WB1:1000 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:JTK3, AIIDE, JAK1A, JAK1B, JAK1
Positive Sample:Mouse lung
Cellular Localization:Cytoplasm, Cytoskeleton, Cytosol, Endosome, Focal Adhesion, Nucleus.
Calculated MW:133kDa
Observed MW:130kDa

This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants.

Purification MethodAffinity purification
Gene ID3716
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of lysates from Mouse lung using JAK1 Rabbit mAb (CAB11963) at 1:1000 dilution incubated overnight at 4℃. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 180s.
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