Anti-JAK1 Antibody (CAB11963)

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SKU:

CAB11963

Product type:

Antibody

Antibody Type:

Monoclonal Antibody

Reactivity:

Human

Reactivity:

Mouse

Reactivity:

Rat

Host Species:

Rabbit

Isotype:

IgG

Synonyms:

JAK1A

Synonyms:

JAK1B

Synonyms:

JTK3

Description

Description

UniProt Protein Function:	JAK1: a widely expressed non-receptor tyrosine-kinase involved in the interferon-alpha/beta and -gamma signal transduction pathways. Couples cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. A selective Jak1 inhibitor induces apoptosis in NRP-154 prostate cancer cell line. A single mutation seen in tyrosine kinome screen of colon cancers. Activated in B cell lines from patients with post-transplant lymphoproliferative disorder, and in a mouse Lck-driven T cell lymphoma. Inhibitor: Piceatannol.
UniProt Protein Details:	Protein type:Kinase, protein; EC 2.7.10.2; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; JakA family Chromosomal Location of Human Ortholog: 1p32.3-p31.3 Cellular Component: cytoplasm; cytoskeleton; cytosol; endomembrane system; extrinsic to internal side of plasma membrane; focal adhesion; nucleus Molecular Function:ATP binding; CCR5 chemokine receptor binding; growth hormone receptor binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein phosphatase binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor binding; ubiquitin protein ligase binding Biological Process: cell differentiation; cell migration; innate immune response; MAPKKK cascade; positive regulation of GTPase activity; protein amino acid phosphorylation; regulation of cell proliferation; response to antibiotic; transmembrane receptor protein tyrosine kinase signaling pathway
NCBI Summary:	This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
UniProt Code:	P23458
NCBI GenInfo Identifier:	215274013
NCBI Gene ID:	3716
NCBI Accession:	P23458.2
UniProt Secondary Accession:	P23458,Q59GQ2, Q9UD26,
UniProt Related Accession:	P23458
Molecular Weight:
NCBI Full Name:	Tyrosine-protein kinase JAK1
NCBI Synonym Full Names:	Janus kinase 1
NCBI Official Symbol:	JAK1
NCBI Official Synonym Symbols:	JTK3; JAK1A; JAK1B
NCBI Protein Information:	tyrosine-protein kinase JAK1
UniProt Protein Name:	Tyrosine-protein kinase JAK1
UniProt Synonym Protein Names:	Janus kinase 1; JAK-1
Protein Family:	Tyrosine-protein kinase
UniProt Gene Name:	JAK1
UniProt Entry Name:	JAK1_HUMAN

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