Anti-hnRNP E1/PCBP1 Antibody (CAB19276)
- SKU:
- CAB19276
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PCBP1
- Synonyms:
- HEL-S-85
- Synonyms:
- HNRPE1
- Synonyms:
- HNRPX
- Synonyms:
- hnRNP-E1
- Synonyms:
- hnRNP-X
- Synonyms:
- poly(rC)-binding protein 1
Frequently bought together:
Description
| 抗体名: | hnRNP E1/PCBP1 Rabbit mAb |
| 抗体コード: | CAB19276 |
| サイズ: | 20uL, 50uL, 100uL |
| 同義語: | PCBP1, HEL-S-85, HNRPE1, HNRPX, hnRNP-E1, hnRNP-X, poly(rC)-binding protein 1 |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human hnRNP E1/hnRNP E1/PCBP1. |
| 申し込み: | WB |
| 推奨される希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, HepG2, A-431, K-562, Mouse lung, Mouse brain, Rat pancreas |
| 免疫原: | Recombinant protein of human hnRNP E1/hnRNP E1/PCBP1. |
| 精製方法: | Affinity purification |
| 保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 5093 |
| Uniprot: | Q15365 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 40kDa |
| 観察された分子量: | 40KDa |
| UniProt Protein Function: | hnRNP E1: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands. |
| UniProt Protein Details: | Protein type:Translation; RNA splicing; RNA-binding Chromosomal Location of Human Ortholog: 2p13-p12 Cellular Component: cytoplasm; intracellular membrane-bound organelle; membrane; nucleoplasm Molecular Function:mRNA binding; protein binding; RNA binding; single-stranded DNA binding Biological Process: gene expression; nuclear mRNA splicing, via spliceosome |
| NCBI Summary: | This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15365 |
| NCBI GenInfo Identifier: | 42560548 |
| NCBI Gene ID: | 5093 |
| NCBI Accession: | Q15365.2 |
| UniProt Secondary Accession: | Q15365,Q13157, Q14975, |
| UniProt Related Accession: | Q15365 |
| Molecular Weight: | 37,498 Da |
| NCBI Full Name: | Poly(rC)-binding protein 1 |
| NCBI Synonym Full Names: | poly(rC) binding protein 1 |
| NCBI Official Symbol: | PCBP1 |
| NCBI Official Synonym Symbols: | HNRPX; HNRPE1; hnRNP-X; HEL-S-85; hnRNP-E1 |
| NCBI Protein Information: | poly(rC)-binding protein 1 |
| UniProt Protein Name: | Poly(rC)-binding protein 1 |
| UniProt Synonym Protein Names: | Alpha-CP1; Heterogeneous nuclear ribonucleoprotein E1; hnRNP E1; Nucleic acid-binding protein SUB2.3 |
| Protein Family: | Poly(rC)-binding protein |
| UniProt Gene Name: | PCBP1 |
| UniProt Entry Name: | PCBP1_HUMAN |
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