Anti-CDKN1A Antibody (CAB20471)

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SKU:

CAB20471

Product type:

Antibody

Antibody Type:

Polyclonal Antibody

Reactivity:

Mouse

Reactivity:

Rat

Host Species:

Rabbit

Isotype:

IgG

Synonyms:

CAP

Synonyms:

CDK

Synonyms:

P21

Synonyms:

Waf

Synonyms:

mda

Synonyms:

CDKI

Synonyms:

CIP1

Synonyms:

Cdkn

Synonyms:

SDI1

Synonyms:

Waf1

Synonyms:

mda6

Synonyms:

p21C

Synonyms:

p21W

Synonyms:

CAP20

Synonyms:

Cdkn1

Synonyms:

p21WAF

Synonyms:

p21Cip1

Description

Description

UniProt Protein Function:	p21Cip1: a cell-cycle regulatory protein that Interacts with cyclin-CDK2 and -CDK4, inhibiting cell cycle progression at G1. Its expression is tightly controlled by p53, through which this protein mediates the p53-dependent cell cycle arrest at G1 phase.
UniProt Protein Details:	Protein type:Inhibitor; Cell cycle regulation Cellular Component: cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; nucleus; perinuclear region of cytoplasm Molecular Function:cyclin binding; cyclin-dependent protein kinase activating kinase activity; cyclin-dependent protein kinase inhibitor activity; protein binding; protein complex binding; ubiquitin protein ligase binding Biological Process: cell cycle arrest; cellular response to amino acid starvation; cellular response to extracellular stimulus; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; negative regulation of apoptosis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of phosphorylation; positive regulation of B cell proliferation; positive regulation of fibroblast proliferation; positive regulation of programmed cell death; regulation of cell cycle; regulation of cyclin-dependent protein kinase activity; regulation of mitotic cell cycle; regulation of protein import into nucleus, translocation; response to DNA damage stimulus; response to UV
NCBI Summary:	This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at the G1 pahse. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
UniProt Code:	P39689
NCBI GenInfo Identifier:	1705726
NCBI Gene ID:	12575
NCBI Accession:	P39689.4
UniProt Related Accession:	P39689
Molecular Weight:	17,785 Da
NCBI Full Name:	Cyclin-dependent kinase inhibitor 1
NCBI Synonym Full Names:	cyclin-dependent kinase inhibitor 1A (P21)
NCBI Official Symbol:	Cdkn1a
NCBI Official Synonym Symbols:	P21; CDKI; CIP1; SDI1; Waf1; mda6; CAP20; Cdkn1; p21WAF; p21Cip1
NCBI Protein Information:	cyclin-dependent kinase inhibitor 1
UniProt Protein Name:	Cyclin-dependent kinase inhibitor 1
UniProt Synonym Protein Names:	CDK-interacting protein 1; Melanoma differentiation-associated protein; p21
UniProt Gene Name:	Cdkn1a
UniProt Entry Name:	CDN1A_MOUSE

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