Anti-CASP1 Antibody (CAB20470)
- SKU:
- CAB20470
- Product type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- IC
- Synonyms:
- ICE
- Synonyms:
- Il1
- Synonyms:
- Casp
- Synonyms:
- Il1bc
Description
抗体名: | CASP1 Rabbit pAb |
抗体コード: | CAB20470 |
サイズ: | 50uL, 100uL |
同義語: | IC, ICE, Il1, Casp, Il1bc |
申し込み: | WB, IF |
反応性: | Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant protein of Mouse CASP1. |
申し込み: | WB, IF |
推奨される希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Mouse, Rat |
ポジティブサンプル: | Mouse testis |
免疫原: | Recombinant protein of Mouse CASP1. |
精製方法: | Affinity purification |
保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 12362 |
Uniprot: | P29452 |
計算された分子量: | 45kDa |
観察された分子量: | 48KDa |
UniProt Protein Function: | CASP1: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Interacts with CARD17/INCA and CARD18. Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. Specifically inhibited by the cowpox virus Crma protein. Belongs to the peptidase C14A family. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Apoptosis; EC 3.4.22.36; Protease Cellular Component: neuron projection; protein complex; mitochondrion; cytoplasm; extracellular region; nucleus Molecular Function:peptidase activity; protein binding; hydrolase activity; endopeptidase activity; cysteine-type peptidase activity Biological Process: response to drug; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptosis; apoptosis; membrane hyperpolarization; microglial cell activation; interleukin-1 beta production; response to lipopolysaccharide; mitochondrial depolarization; positive regulation of interleukin-1 beta secretion; proteolysis; response to organic cyclic substance; memory; response to ATP; positive regulation of interleukin-1 alpha secretion; regulation of apoptosis; response to bacterium; regulation of inflammatory response; response to hypoxia; protein processing; regulation of autophagy; positive regulation of circadian sleep/wake cycle, non-REM sleep; myoblast fusion; positive regulation of cytokine secretion |
UniProt Code: | P29452 |
NCBI GenInfo Identifier: | 266322 |
NCBI Gene ID: | 12362 |
NCBI Accession: | P29452.1 |
UniProt Related Accession: | P29452 |
Molecular Weight: | |
NCBI Full Name: | Caspase-1 |
NCBI Synonym Full Names: | caspase 1 |
NCBI Official Symbol: | Casp1 |
NCBI Official Synonym Symbols: | ICE; Il1bc |
NCBI Protein Information: | caspase-1; p45; CASP-1; IL-1BC; IL-1B converting enzyme; IL-1 beta-converting enzyme; interleukin-1 beta convertase; interleukin 1 beta-converting enzyme; interleukin-1 beta-converting enzyme |
UniProt Protein Name: | Caspase-1 |
UniProt Synonym Protein Names: | Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45Cleaved into the following 2 chains:Caspase-1 subunit p20; Caspase-1 subunit p10 |
UniProt Gene Name: | Casp1 |
UniProt Entry Name: | CASP1_MOUSE |