Anti-ATF4 Antibody [N360A/24 (Formerly sold as S360A-24)]

ATF4 Antibody [N360A/24 (Formerly sold as S360A-24)]

ATF4 Antibody [N360A/24 (Formerly sold as S360A-24)] is a mouse monoclonal antibody directed against ATF4, offered by Assay Genie for research applications. Reported applications include WB, IHC and ICC/IF. Reported reactivity: Human and Rat. Supplied as IgG2a, purified by Protein G.

Activating Transcription Factor 4 (ATF4) is a key basic leucine zipper (bZIP) transcription factor that orchestrates cellular responses to endoplasmic reticulum (ER) stress, oxidative stress, and nutrient deprivation—conditions commonly implicated in neurodegenerative diseases. ATF4 regulates critical pathways including amino acid metabolism, DNA damage repair, chromatin remodeling, and apoptosis, positioning it as a central node in maintaining neuronal homeostasis. In the nervous system, ATF4 functions as a stress-responsive transcriptional regulator, often in coordination with proteins such as CHOP (C/EBP homologous protein), asparagine synthetase (ASNS), and cAMP response elements (CREs). These interactions modulate gene expression programs that determine cell survival or death under pathological conditions. Notably, ATF4 suppresses pancreatic β-cell proliferation and insulin production, linking metabolic dysfunction to neurodegenerative processes. ATF4 also influences epigenetic regulation by targeting the histone demethylase JMJD3, thereby altering chromatin architecture and enhancing transcriptional responses to amino acid scarcity. This epigenetic control is particularly relevant in neurons, where adaptive gene expression is essential for coping with chronic stress. Given its multifaceted role in stress signaling, ATF4 is increasingly recognized as a therapeutic target in neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). Ongoing research into ATF4-mediated pathways offers promising insights into the molecular mechanisms driving neuronal vulnerability and resilience. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.