Anti-ABHD5 Antibody (CAB8673)

(No reviews yet) Write a Review
SKU:
CAB8673
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CDS
Synonyms:
CGI58
Synonyms:
IECN2
Synonyms:
NCIE2
€0.00
Frequently bought together:

Description

I抗体名:ABHD5 Rabbit mAb
抗体コード:CAB8673
サイズ:20uL, 50uL, 100uL
同義語:CDS, CGI58, IECN2, NCIE2
申し込み:WB
反応性:Human, Rat
宿主種:Rabbit
免疫原:A synthesized peptide derived from human ABHD5
申し込み:WB
推奨される希釈:WB 1:500 - 1:2000
反応性:Human, Rat
ポジティブサンプル:HepG2, RD, Rat liver, Rat testis
免疫原:A synthesized peptide derived from human ABHD5
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:51099
Uniprot:Q8WTS1
セルラーロケーション:Cytoplasm, Lipid droplet
計算された分子量:45kDa
観察された分子量:42kDa
UniProt Protein Function:ABHD5: a lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Colocalized with PLIN and ADFP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA. Defects cause neutral lipid storage disease (NLSD), an autosomal recessive disorder characterized by the excessive accumulation of neutral lipids in multiple tissues, and Chanarin-Dorfman syndrome (CDS), a triglyceride storage disease with impaired long-chain fatty acid oxidation and icthyosis. CDS is an autosomal recessive inborn error of lipid metabolism with multisystemic accumulation of triglycerides although plasma concentrations are normal. Widely expressed in various tissues, including lymphocytes, liver, skeletal muscle and brain. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and neurons.
UniProt Protein Details:

Protein type:Transferase; EC 2.3.1.51; Lipase

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: intracellular membrane-bound organelle; cytoplasm; lipid particle; nucleus; cytosol

Molecular Function:triacylglycerol lipase activity; 1-acylglycerol-3-phosphate O-acyltransferase activity; lysophosphatidic acid acyltransferase activity

Biological Process: triacylglycerol catabolic process; phosphatidic acid biosynthetic process; positive regulation of lipoprotein lipase activity; fatty acid metabolic process; cell differentiation

Disease: Chanarin-dorfman Syndrome

NCBI Summary:The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation. [provided by RefSeq, Jul 2008]
UniProt Code:Q8WTS1
NCBI GenInfo Identifier:73921640
NCBI Gene ID:51099
NCBI Accession:Q8WTS1.1
UniProt Secondary Accession:Q8WTS1,Q9Y369, B2R9K0,
UniProt Related Accession:Q8WTS1
Molecular Weight:
NCBI Full Name:1-acylglycerol-3-phosphate O-acyltransferase ABHD5
NCBI Synonym Full Names:abhydrolase domain containing 5
NCBI Official Symbol:ABHD5  
NCBI Official Synonym Symbols:CDS; CGI58; IECN2; NCIE2  
NCBI Protein Information:1-acylglycerol-3-phosphate O-acyltransferase ABHD5; lipid droplet-binding protein CGI-58; abhydrolase domain-containing protein 5
UniProt Protein Name:1-acylglycerol-3-phosphate O-acyltransferase ABHD5
UniProt Synonym Protein Names:Abhydrolase domain-containing protein 5; Lipid droplet-binding protein CGI-58
Protein Family:1-acylglycerol-3-phosphate O-acyltransferase
UniProt Gene Name:ABHD5  
UniProt Entry Name:ABHD5_HUMAN
View AllClose

View AllClose

Related Products