TRIM27 Antibody (PACO20695)
- SKU:
- PACO20695
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | TRIM27 Antibody (PACO20695) |
抗体コード: | PACO20695 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
反応性: | Human, Mouse |
免疫原: | Synthetic peptide of human TRIM27 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20695(TRIM27 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20695(TRIM27 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. |
シノニム: | tripartite motif containing 27 |
UniProt Protein Function: | TRIM27: Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Defects in TRIM27 are a cause of thyroid papillary carcinoma (TPC). TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. A chromosomal aberration involving TRIM27/RFP is found in thyroid papillary carcinomas. Translocation t(6;10)(p21.3;q11.2) with RET. The translocation generates TRIM27/RET and delta TRIM27/RET oncogenes. Belongs to the TRIM/RBCC family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; EC 6.3.2.-; Oncoprotein; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 6p22 Cellular Component: cytoplasm; endosome; integral to plasma membrane; membrane; nuclear membrane; nucleoplasm; nucleus; retromer complex Molecular Function:metal ion binding; nucleic acid binding; protein binding; transmembrane receptor protein tyrosine kinase activity; ubiquitin-protein ligase activity Biological Process: cell proliferation; innate immune response; negative regulation of adaptive immune response; negative regulation of gene expression, epigenetic; negative regulation of protein kinase activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of tumor necrosis factor production; negative regulation of viral transcription; positive regulation of transcription factor activity; retrograde transport, endosome to Golgi; spermatogenesis |
NCBI Summary: | This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008] |
UniProt Code: | P14373 |
NCBI GenInfo Identifier: | 132517 |
NCBI Gene ID: | 5987 |
NCBI Accession: | P14373.1 |
UniProt Secondary Accession: | P14373,Q5RJA8, Q5ST26, Q6LA73, Q6NXR9, Q9BZY6, Q9UJL3 A2BE15, |
UniProt Related Accession: | P14373 |
Molecular Weight: | 41,439 Da |
NCBI Full Name: | Zinc finger protein RFP |
NCBI Synonym Full Names: | tripartite motif containing 27 |
NCBI Official Symbol: | TRIM27 |
NCBI Official Synonym Symbols: | RFP; RNF76 |
NCBI Protein Information: | zinc finger protein RFP |
UniProt Protein Name: | Zinc finger protein RFP |
UniProt Synonym Protein Names: | RING finger protein 76; Ret finger protein; Tripartite motif-containing protein 27 |
Protein Family: | Zinc finger protein |
UniProt Gene Name: | TRIM27 |
UniProt Entry Name: | TRI27_HUMAN |