TPT1 Antibody (PACO54402)
- SKU:
- PACO54402
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TPT1 Antibody (PACO54402) |
抗体コード: | PACO54402 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Translationally-controlled tumor protein (1-172AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO54402 at dilution of 1:100. | |
Immunofluorescence staining of Hela cells with PACO54402 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Involved in calcium binding and microtubule stabilization. |
シノニム: | Translationally-controlled tumor protein (TCTP) (Fortilin) (Histamine-releasing factor) (HRF) (p23), TPT1 |
UniProt Protein Function: | TPT1: a novel heat shock protein with antiapoptotic and chaperone-like activity. Its levels are highly regulated in response to various cellular stimuli and stresses. Downregulated in response to proapoptotic treatments that induce Ca(++) stress, in a PKR-dependent manner. Colocalizes with CHFR to the mitotic spindle. Appears to be involved in calcium binding and microtubule stabilization. Its exosomal secretion is induced following DNA damage. Interacts with MCL1 and STEAP3, a p53-inducible transmembrane protein that facilitates the exosomal secretion of TPT1. Secreted TPT1 acts as a histamine-releasing factor, participates in inflammatory responses by inducing the release of histamine, and may play a role in tumor reversion. May play a direct role in placental calcium transport. Phosphorylation by Plk may decrease its microtubule-stabilizing activity and promote microtubule dynamics following metaphase. Critical for peripheral T cell maintenance and TCR-mediated cell proliferation. |
UniProt Protein Details: | Protein type:Calcium-binding; Microtubule-binding Chromosomal Location of Human Ortholog: 13q14 Cellular Component: multivesicular body; extracellular space; tubulin complex; cytoplasm; nucleus Molecular Function:protein binding; calcium ion binding Biological Process: regulation of apoptosis; cellular calcium ion homeostasis; response to virus; calcium ion transport; negative regulation of apoptosis |
UniProt Code: | P13693 |
NCBI GenInfo Identifier: | 136479 |
NCBI Gene ID: | 7178 |
NCBI Accession: | P13693.1 |
UniProt Secondary Accession: | P13693,Q6YLS2, Q7Z4J4, Q8TBK7, Q96EE2, Q9UC70, B2R7E5 |
UniProt Related Accession: | P13693 |
Molecular Weight: | 172 |
NCBI Full Name: | Translationally-controlled tumor protein |
NCBI Synonym Full Names: | tumor protein, translationally-controlled 1 |
NCBI Official Symbol: | TPT1 |
NCBI Official Synonym Symbols: | HRF; p02; p23; TCTP |
NCBI Protein Information: | translationally-controlled tumor protein; fortilin; histamine-releasing factor |
UniProt Protein Name: | Translationally-controlled tumor protein |
UniProt Synonym Protein Names: | Fortilin; Histamine-releasing factor; HRF; p23 |
Protein Family: | TPT1-like protein |
UniProt Gene Name: | TPT1 |
UniProt Entry Name: | TCTP_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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