UniProt Protein Function: | Function: Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1.Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein Potential. Tissue specificity: Ubiquitous.Sequence similarities: Belongs to the glycosyltransferase 29 family. |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene is a member of the sialyltransferase family. Members of this family are enzymes that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates and may contribute to the formation of selectin ligands and sialyl Lewis X, a carbohydrate important for cell-to-cell recognition and a blood group antigen. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Sep 2012] |
UniProt Code: | Q9Y274 |
NCBI GenInfo Identifier: | 403225032 |
NCBI Gene ID: | 10402 |
NCBI Accession: | NP_001258074.1 |
UniProt Secondary Accession: | Q9Y274,B2RCH2, B3KMI1, D3DN39, F8W6U0 |
UniProt Related Accession: | Q9Y274 |
Molecular Weight: | 38,214 Da |
NCBI Full Name: | type 2 lactosamine alpha-2,3-sialyltransferase isoform 3 |
NCBI Synonym Full Names: | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 |
NCBI Official Symbol: | ST3GAL6 |
NCBI Official Synonym Symbols: | SIAT10; ST3GALVI |
NCBI Protein Information: | type 2 lactosamine alpha-2,3-sialyltransferase; alpha2,3-sialyltransferase ST3Gal VI; sialyltransferase 10 (alpha-2,3-sialyltransferase VI); CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI |
UniProt Protein Name: | Type 2 lactosamine alpha-2,3-sialyltransferase |
UniProt Synonym Protein Names: | CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI; ST3Gal VI; ST3GalVI; Sialyltransferase 10 |
Protein Family: | |
UniProt Gene Name: | ST3GAL6 |
UniProt Entry Name: | SIA10_HUMAN |