| UniProt Protein Function: | SLC4A5: Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH. Belongs to the anion exchanger (TC 2.A.31) family. 8 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Chromosomal Location of Human Ortholog: 2p13.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:anion transmembrane transporter activity; sodium:bicarbonate symporter activity Biological Process: bicarbonate transport; regulation of intracellular pH; renal system process |
| NCBI Summary: | This gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, part of the bicarbonate transporter superfamily. Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or electrogenic sodium bicarbonate transport. This protein is thought to be an integral membrane protein. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BY07 |
| NCBI GenInfo Identifier: | 182691595 |
| NCBI Gene ID: | 57835 |
| NCBI Accession: | Q9BY07.2 |
| UniProt Secondary Accession: | Q9BY07,Q32MA7, Q59EQ9, Q8WXD3, Q8WXD7, Q96DS7, Q96DS8 Q9HBU5, |
| UniProt Related Accession: | Q9BY07 |
| Molecular Weight: | 126kDa |
| NCBI Full Name: | Electrogenic sodium bicarbonate cotransporter 4 |
| NCBI Synonym Full Names: | solute carrier family 4 member 5 |
| NCBI Official Symbol: | SLC4A5 |
| NCBI Official Synonym Symbols: | NBC4; NBCe2 |
| NCBI Protein Information: | electrogenic sodium bicarbonate cotransporter 4 |
| UniProt Protein Name: | Electrogenic sodium bicarbonate cotransporter 4 |
| UniProt Synonym Protein Names: | NBCe2; Solute carrier family 4 member 5 |
| Protein Family: | Electrogenic sodium bicarbonate cotransporter |
| UniProt Gene Name: | SLC4A5 |
