UniProt Protein Function: | KCC3: Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells. Homomultimer and heteromultimer with other K-Cl cotransporters. Up-regulated by VEGF. Down-regulated by TNF. Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific. Expressed in the proximal tubule of the kidney. Activated by N-ethylmaleimide (NEM). Inhibited by DIOA, bumetanide and furosemide. Inhibited by WNK3. Belongs to the SLC12A transporter family. 6 isoforms of the human protein are produced by alternative promoter. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Transporter, SLC family; Transporter; Membrane protein, integral Chromosomal Location of Human Ortholog: 15q13 Cellular Component: basolateral plasma membrane; integral to plasma membrane; integral to membrane; plasma membrane Molecular Function:potassium ion transmembrane transporter activity; protein kinase binding; potassium:chloride symporter activity Biological Process: potassium ion import; ion transport; angiogenesis; transmembrane transport; potassium ion transport Disease: Agenesis Of The Corpus Callosum With Peripheral Neuropathy |
NCBI Summary: | This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UHW9 |
NCBI GenInfo Identifier: | 110224449 |
NCBI Gene ID: | 9990 |
NCBI Accession: | NP_598408.1 |
UniProt Secondary Accession: | Q9UHW9,Q2VI00, Q7Z2E7, Q7Z4G5, Q8TDD4, Q9UFR2, Q9Y642 Q9Y665, A0AV76, |
UniProt Related Accession: | Q9UHW9 |
Molecular Weight: | 120,467 Da |
NCBI Full Name: | solute carrier family 12 member 6 isoform a |
NCBI Synonym Full Names: | solute carrier family 12 member 6 |
NCBI Official Symbol: | SLC12A6 |
NCBI Official Synonym Symbols: | KCC3; ACCPN; KCC3A; KCC3B |
NCBI Protein Information: | solute carrier family 12 member 6 |
UniProt Protein Name: | Solute carrier family 12 member 6 |
UniProt Synonym Protein Names: | Electroneutral potassium-chloride cotransporter 3; K-Cl cotransporter 3 |
Protein Family: | Solute carrier family |
UniProt Gene Name: | SLC12A6 |
UniProt Entry Name: | S12A6_HUMAN |