Description
| 抗体名: | SF1 Antibody |
| 抗体コード: | PACO01530 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC, IF |
| 推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| 反応性: | Human, Mouse |
| 免疫原: | synthesized peptide derived from human Splicing factor 1 around the non-phosphorylation site of S82. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | SF1; ZFM1; ZNF162; Splicing factor 1; Mammalian branch point-binding protein; BBP; mBBP; Transcription factor ZFM1; Zinc finger gene in MEN1 locus; Zinc finger protein 162 |
| UniProt Protein Function: | SF1: a splicing factor necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. Phosphorylation of SF1 by cGMP-dependent protein kinase regulates spliceosome assembly. Binds U2AF2. Interacts with U1 snRNA. Binds EWSR1, FUS and TAF15. Six alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; Spliceosome; RNA splicing; RNA-binding Chromosomal Location of Human Ortholog: 11q13 Cellular Component: nucleoplasm; spliceosome; ribosome; nucleus Molecular Function:zinc ion binding; RNA binding; transcription corepressor activity Biological Process: nuclear mRNA 3'-splice site recognition; nuclear mRNA splicing, via spliceosome; Leydig cell differentiation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; negative regulation of smooth muscle cell proliferation; male sex determination; spliceosome assembly; regulation of steroid biosynthetic process |
| NCBI Summary: | This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence and is required for the early stages of spliceosome assembly. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010] |
| UniProt Code: | Q15637 |
| NCBI GenInfo Identifier: | 38258418 |
| NCBI Gene ID: | 7536 |
| NCBI Accession: | Q15637.4 |
| UniProt Secondary Accession: | Q15637,Q14818, Q14819, Q15913, Q8IY00, Q92744, Q92745 Q969H7, Q9BW01, Q9UEI0, B7Z1Q1, C9JJE2, |
| UniProt Related Accession: | Q15637 |
| Molecular Weight: | 65,371 Da |
| NCBI Full Name: | Splicing factor 1 |
| NCBI Synonym Full Names: | splicing factor 1 |
| NCBI Official Symbol: | SF1 |
| NCBI Official Synonym Symbols: | BBP; MBBP; ZFM1; ZNF162; D11S636; ZCCHC25 |
| NCBI Protein Information: | splicing factor 1; zinc finger protein 162; transcription factor ZFM1; zinc finger gene in MEN1 locus; mammalian branch point-binding protein |
| UniProt Protein Name: | Splicing factor 1 |
| UniProt Synonym Protein Names: | Mammalian branch point-binding protein; BBP; mBBP; Transcription factor ZFM1; Zinc finger gene in MEN1 locus; Zinc finger protein 162 |
| Protein Family: | Splicing factor |
| UniProt Gene Name: | SF1 |
| UniProt Entry Name: | SF01_HUMAN |
