| UniProt Protein Function: | Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA. |
| UniProt Protein Details: | |
| NCBI Summary: | Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L13P family of ribosomal proteins that is a component of the 60S subunit. The encoded protein also plays a role in the repression of inflammatory genes as a component of the IFN-gamma-activated inhibitor of translation (GAIT) complex. This gene is co-transcribed with the small nucleolar RNA genes U32, U33, U34, and U35, which are located in the second, fourth, fifth, and sixth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] |
| UniProt Code: | P40429 |
| NCBI GenInfo Identifier: | 395132450 |
| NCBI Gene ID: | 23521 |
| NCBI Accession: | NP_001257420.1 |
| UniProt Secondary Accession: | P40429,A8K505 |
| UniProt Related Accession: | P40429 |
| Molecular Weight: | 22 |
| NCBI Full Name: | 60S ribosomal protein L13a isoform 2 |
| NCBI Synonym Full Names: | ribosomal protein L13a |
| NCBI Official Symbol: | RPL13A |
| NCBI Official Synonym Symbols: | L13A; TSTA1 |
| NCBI Protein Information: | 60S ribosomal protein L13a |
| UniProt Protein Name: | 60S ribosomal protein L13a |
| UniProt Synonym Protein Names: | 23 kDa highly basic protein; Large ribosomal subunit protein uL13 |
| Protein Family: | |
| UniProt Gene Name: | RPL13A |
| UniProt Entry Name: | |
