| UniProt Protein Function: | RIPK3: Promotes apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Binds TRAF2 and RIPK1 and is recruited to the TNFR-1 signaling complex. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Kinase, protein; TKL group; RIPK family Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: mitochondrion; plasma membrane; cytosol Molecular Function:NF-kappaB-inducing kinase activity; protein serine/threonine kinase activity; identical protein binding; protein binding; transcription coactivator activity; protein complex binding; ATP binding; protein kinase activity Biological Process: spleen development; I-kappaB kinase/NF-kappaB cascade; regulation of activated T cell proliferation; thymus development; protein heterooligomerization; protein amino acid autophosphorylation; MyD88-independent toll-like receptor signaling pathway; T cell differentiation in the thymus; protein modification process; toll-like receptor 3 signaling pathway; signal transduction; lymph node development; activation of NF-kappaB transcription factor; regulation of T cell mediated cytotoxicity; regulation of adaptive immune response; regulation of interferon-gamma production; toll-like receptor signaling pathway; positive regulation of interferon type I production; activation of protein kinase activity; innate immune response; T cell homeostasis; positive regulation of ligase activity; toll-like receptor 4 signaling pathway; protein homooligomerization; positive regulation of oxidoreductase activity |
| UniProt Code: | Q9Y572 |
| NCBI GenInfo Identifier: | 40254844 |
| NCBI Gene ID: | 11035 |
| NCBI Accession: | NP_006862 |
| UniProt Secondary Accession: | Q9Y572,Q5J795, Q5J796, Q6P5Y1, B4DJL9, C4AM87, |
| UniProt Related Accession: | Q9Y572 |
| Molecular Weight: | 25,326 Da |
| NCBI Full Name: | receptor-interacting serine/threonine-protein kinase 3 |
| NCBI Synonym Full Names: | receptor-interacting serine-threonine kinase 3 |
| NCBI Official Symbol: | RIPK3 |
| NCBI Official Synonym Symbols: | RIP3 |
| NCBI Protein Information: | receptor-interacting serine/threonine-protein kinase 3; RIP-3; RIP-like protein kinase 3; receptor interacting protein 3; receptor-interacting protein 3 |
| UniProt Protein Name: | Receptor-interacting serine/threonine-protein kinase 3 |
| UniProt Synonym Protein Names: | RIP-like protein kinase 3; Receptor-interacting protein 3; RIP-3 |
| Protein Family: | Putative zinc metalloprotease |
| UniProt Gene Name: | RIPK3 |
| UniProt Entry Name: | RIPK3_HUMAN |
