Immunology

// system_update_altDatasheetsystem_update_altMSDSOverviewProduct Name:PF 4 Protein Recombinant ProteinProduct Code:RPPB1254Size:20µgTarget:PF 4 ProteinSynonyms:CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298.Source:Human...

// Human NRG1 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary...

// Human HGF Recombinant Protein (hFc Tag)Description:This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results...

// Human CCR8 Recombinant Protein (hFc Tag)Description:This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are...

// Human IL21 Recombinant Protein (hFc Tag)Description:This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing...

// Human IL20 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of...

// Human IL18R1 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated...

// Human GPC1 Recombinant Protein (hFc Tag)Description:Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral...

// Human TM4SF1 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the...

// Human IL18 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells...

// Human IL1A Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and...

// Human DKK2 Recombinant Protein (hFc Tag)Description:This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the...

// Human VSIR Recombinant Protein (hFc Tag)Description:Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate...

// Human TLR3 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved...

// Human SIGLEC9 Recombinant Protein (hFc Tag)Description:Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked...

// Human LGALS3 Recombinant Protein (hFc Tag)Description:This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an...

// Human KRAS Recombinant Protein (hFc Tag)Description:This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for...

// Human IFNAR1 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus...

// Human HBL Recombinant Protein (hFc Tag)Description:The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that...

// Human Gastrin Recombinant Protein (hFc Tag)Description:Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic...

// Human FN1 Recombinant Protein (hFc Tag)Description:This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded...

// system_update_altDatasheetHuman CXCR2 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high...

// Human CSF2RA Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of...

// Human CCR2 Recombinant Protein (hFc Tag)Description:This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in...

// Human CB2 Recombinant Protein (hFc Tag)Description:The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the...

// Human ADAM9 Recombinant Protein (hFc Tag)Description:This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and...

// Human IL1R1 Recombinant Protein (hFc Tag)Description:This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor...

// Human NECTIN4 Recombinant Protein (hFc Tag)Description:This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion...

// Human GDNF Recombinant Protein (hFc Tag)Description:This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and...

// Human FOLR2 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic...

// Human PROM1 Recombinant Protein (hFc Tag)Description:This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining...

// Human VSIG4 Recombinant Protein (hFc Tag)Description:This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of...

// Human NCR1 Recombinant Protein (hFc Tag)Description:Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.Product name:Human NCR1 Recombinant Protein (hFc...

// Human KLRC1 Recombinant Protein (hFc Tag)Description:Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and...

// Human IL1B Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active...

// Human LRRC32 Recombinant Protein (hFc Tag)Description:This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies.Product name:Human LRRC32 ...

// Human CXC-R5 Recombinant Protein (hFc Tag)Description:This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to...

// Human CXC-R4 Recombinant Protein (hFc Tag)Description:This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to...

// Human CXC-R3 Recombinant Protein (hFc Tag)Description:This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and...

// Human CLEC2D Recombinant Protein (hFc Tag)Description:This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as...

// Human CEACAM-1 Recombinant Protein (hFc Tag)Description:This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and...

// Human CCR9 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their...

// Human CCR7 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator...

// Human CCR4 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide,...

// Human CEACAM6 Recombinant Protein (hFc Tag)Description:This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this...

// Human IGF-1R Recombinant Protein (hFc Tag)Description:This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events...

// Human ANPEP Recombinant Protein (hFc Tag)Description:Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion...

// Human IL4RA Recombinant Protein (hFc Tag)Description:This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also...

// Human GPA33 Recombinant Protein (hFc Tag)Description:The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a...

// Human AMHR2 Recombinant Protein (hFc Tag)Description:This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by...

// Human IL15RA Recombinant Protein (hFc Tag)Description:This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the...

// Human MUC1 Recombinant Protein (hFc Tag)Description:This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial...

// Human PSMA Recombinant Protein (mFc Tag)Description:This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the...

// Human PSMA Recombinant Protein (His Tag)Description:This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the...

// Human YAP1 Recombinant Protein (His Tag)Description:This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development...

// Human TMEM173 Recombinant Protein (hFc Tag)Description:This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition...

// Human SLAMF3 Recombinant Protein (His Tag)Description:LY9 belongs to the SLAM family of immunomodulatory receptors (see SLAMF1, MIM 603492) and interacts with the adaptor molecule SAP (SH2D1A, MIM 300490) (Graham et al., 2006 [PubMed 16365421])...

// Human TM4SF1 Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the...

// Human IL5 Recombinant Protein (hFc Tag)Description:This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation,...

// Human IL5RA Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta...

// Human IL6R Recombinant Protein (hFc Tag)Description:This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in...

// Human SFRP2 Recombinant Protein (His Tag)Description:This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling...

// Human AXL Recombinant Protein (mFc Tag)Description:The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two...

// Human AXL Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two...

// Human SIRPα Recombinant Protein (mFc Tag)Description:Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein...

// Mouse BTLA Recombinant Protein (His Tag)Description:Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006). May interact in cis (on the same cell) or...

// Mouse BTLA Recombinant Protein (mFc Tag)Description:Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006). May interact in cis (on the same cell) or...

// Human BTLA Recombinant Protein (His Tag)Description:This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune...

// Human BTLA Recombinant Protein (hFc Tag)Description:This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune...

// Human MASP2 Recombinant Protein (hFc Tag)Description:This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature...

// Human PSMA Recombinant Protein (hFc Tag)Description:This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the...

// Human KLRG1 Recombinant Protein (hFc Tag)Description:Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and...

// Human FOLR1 Recombinant Protein (His Tag)Description:The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells...

// Human DKK1 Recombinant Protein (hFc Tag)Description:This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The...

// Human PTK7 Recombinant Protein (hFc Tag)Description:This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic...

// Human AFP Recombinant Protein (hFc Tag)Description:This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatocarcinoma...

// Human TGFB1 Recombinant Protein (hFc Tag)Description:This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and...

// Human SLAMF3 Recombinant Protein (hFc Tag)Description:LY9 belongs to the SLAM family of immunomodulatory receptors (see SLAMF1, MIM 603492) and interacts with the adaptor molecule SAP (SH2D1A, MIM 300490) (Graham et al., 2006 [PubMed 16365421])...

// Human B7-H4 Recombinant Protein (hFc Tag)Description:This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to...

// Human LIGHT Recombinant Protein (hFc Tag)Description:The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor...

// Mouse FAP Recombinant Protein (C-mFc Tag)Description:This gene belongs to the serine protease family. The encoded protein is an inducible cell-surface bound glycoprotein specifically expressed in tumor-associated fibroblasts and pericytes of...

// Mouse FAP Recombinant Protein (N-mFc Tag)Description:This gene belongs to the serine protease family. The encoded protein is an inducible cell-surface bound glycoprotein specifically expressed in tumor-associated fibroblasts and pericytes of...

// Human ANGPTL3 Recombinant Protein (His Tag)Description:This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an...

// Human PDL2 Recombinant Protein (His Tag)Description:Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle...

// Human IL13RA1 Recombinant Protein (His Tag)Description:The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This...

// Human VEGFR2 Recombinant Protein (His Tag)Description:Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain...

// Human PVRIG Recombinant Protein (hFc Tag)Description:Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes...

// Human MICB Recombinant Protein (His Tag)Description:This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T...

// Human Galectin 9 Recombinant Protein (hFc Tag)Description:The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is...

// Human LAG3 Recombinant Protein (hFc Tag)Description:Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal...

// Human LAG3 Recombinant Protein (His Tag)Description:Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal...

// Human BCMA Recombinant Protein (His Tag)Description:B-cell maturation protein (BCMA or BCM), is also known as Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), which is encoded by the TNFRSF17 gene. TNFRSF17 is a cell surface receptor...

// Human ROR1 Recombinant Protein (His Tag)Description:This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that...

// Human MICA Recombinant Protein (His Tag)Description:This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I...

// Human EPHA2 Recombinant Protein (His Tag)Description:This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the...

// Human CSPG4 Recombinant Protein (His Tag)Description:A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes...

// Human PMEL Recombinant Protein (hFc Tag)Description:This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an...

// Human B7-H6 Recombinant Protein (His Tag)Description:B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and...

// Human CB1 Recombinant Protein (hFc Tag)Description:This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid...

// Human VEGFA Recombinant Protein (His Tag)Description:This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and...