UniProt Protein Function: | PLA2G10: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine. Belongs to the phospholipase A2 family. |
UniProt Protein Details: | Protein type:Cell development/differentiation; EC 3.1.1.4; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Motility/polarity/chemotaxis; Phospholipase; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 16p13.12 Cellular Component: extracellular region Molecular Function:phospholipase A2 activity; phospholipase activity Biological Process: axon guidance; cholesterol homeostasis; lysophospholipid transport; negative regulation of transcription factor activity; phosphatidic acid biosynthetic process; positive regulation of cellular protein metabolic process; positive regulation of prostaglandin secretion; regulation of macrophage activation |
NCBI Summary: | This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism. [provided by RefSeq, Nov 2015] |
UniProt Code: | O15496 |
NCBI GenInfo Identifier: | 239938869 |
NCBI Gene ID: | 8399 |
NCBI Accession: | O15496.3 |
UniProt Secondary Accession: | O15496,Q14DU3, Q6NT23, |
UniProt Related Accession: | O15496 |
Molecular Weight: | 18kDa |
NCBI Full Name: | Group 10 secretory phospholipase A2 |
NCBI Synonym Full Names: | phospholipase A2 group X |
NCBI Official Symbol: | PLA2G10 |
NCBI Official Synonym Symbols: | SPLA2; GXPLA2; GXSPLA2; sPLA2-X |
NCBI Protein Information: | group 10 secretory phospholipase A2 |
UniProt Protein Name: | Group 10 secretory phospholipase A2 |
UniProt Synonym Protein Names: | Group X secretory phospholipase A2; GX sPLA2; sPLA2-X; Phosphatidylcholine 2-acylhydrolase 10 |
Protein Family: | Group 10 secretory phospholipase |
UniProt Gene Name: | PLA2G10 |