UniProt Protein Function: | PIGQ: Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. Belongs to the PIGQ family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 2.4.1.198; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Transferase Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: endoplasmic reticulum membrane; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex Molecular Function:phosphatidylinositol N-acetylglucosaminyltransferase activity Biological Process: carbohydrate metabolic process; preassembly of GPI anchor in ER membrane |
NCBI Summary: | This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012] |
UniProt Code: | Q9BRB3 |
NCBI GenInfo Identifier: | 22538450 |
NCBI Gene ID: | 9091 |
NCBI Accession: | NP_004195.2 |
UniProt Secondary Accession: | Q9BRB3,O14927, Q96G00, Q96S22, Q9UJH4, A2IDE1, D3DU52 |
UniProt Related Accession: | Q9BRB3 |
Molecular Weight: | 32,471 Da |
NCBI Full Name: | phosphatidylinositol N-acetylglucosaminyltransferase subunit Q isoform 2 |
NCBI Synonym Full Names: | phosphatidylinositol glycan anchor biosynthesis class Q |
NCBI Official Symbol: | PIGQ |
NCBI Official Synonym Symbols: | GPI1; c407A10.1 |
NCBI Protein Information: | phosphatidylinositol N-acetylglucosaminyltransferase subunit Q |
UniProt Protein Name: | Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q |
UniProt Synonym Protein Names: | N-acetylglucosamyl transferase component GPI1; Phosphatidylinositol-glycan biosynthesis class Q protein; PIG-Q |
Protein Family: | Phosphatidylinositol N-acetylglucosaminyltransferase |
UniProt Gene Name: | PIGQ |
UniProt Entry Name: | PIGQ_HUMAN |