UniProt Protein Function: | PDE1C: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nucleotide Metabolism - purine; Phosphodiesterase; EC 3.1.4.17 Chromosomal Location of Human Ortholog: 7p14.3 Cellular Component: cytosol Molecular Function:calmodulin-dependent cyclic-nucleotide phosphodiesterase activity |
NCBI Summary: | This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016] |
UniProt Code: | Q14123 |
NCBI GenInfo Identifier: | 2499445 |
NCBI Gene ID: | 5137 |
NCBI Accession: | Q14123.1 |
UniProt Secondary Accession: | Q14123,Q14124, Q8NB10, B3KPC6, E9PE92, |
UniProt Related Accession: | Q14123 |
Molecular Weight: | 86,896 Da |
NCBI Full Name: | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C |
NCBI Synonym Full Names: | phosphodiesterase 1C |
NCBI Official Symbol: | PDE1C |
NCBI Official Synonym Symbols: | Hcam3; hCam-3; cam-PDE 1C |
NCBI Protein Information: | calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C |
UniProt Protein Name: | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C |
UniProt Synonym Protein Names: | hCam-3 |
Protein Family: | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase |
UniProt Gene Name: | PDE1C |
UniProt Entry Name: | PDE1C_HUMAN |