Description
| Product Name: | Mouse ICAM1 Recombinant Protein |
| Product Code: | RPPB3727 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | ICAM1 |
| Synonyms: | Intercellular adhesion molecule 1, ICAM-1, Major group rhinovirus receptor, CD54 antigen, ICAM1, BB2, CD54, P3.58 |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The ICAM1 solution (0.5mg/1ml) contains Phosphate-Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | QVSIHPREAF LPQGGSVQVN CSSSCKEDLS LGLETQWLKD ELESGPNWKL FELSEIGEDS SPLCFENCGT VQSSASATIT VYSFPESVEL RPLPAWQQVG KDLTLRCHVD GGAPRTQLSA VLLRGEEILS RQPVGGHPKD PKEITFTVLA SRGDHGANFS CRTELDLRPQ GLALFSNVSE ARSLRTFDLP ATIPKLDTPD LLEVGTQQKL FCSLEGLFPA SEARIYLELG GQMPTQESTN SSDSVSATAL VEVTEEFDRT LPLRCVLELA DQILETQRTL TVYNFSAPVL TLSQLEVSEG SQVTVKCEAH SGSKVVLLSG VEPRPPTPQV QFTLNASSED HKRSFFCSAA LEVAGKFLFK NQTLELHVLY GPRLDETDCL GNWTWQEGSQ QTLKCQAWGN PSPKMTCRRK ADGALLPIGV VKSVKQEMNG TYVCHAFSSH GNVTRNVYLT VLYHSQNNVE HHHHHH |
Intercellular adhesion molecule 1 or ICAM1 is a protein, part of the ICAM family of proteins. ICAM1 acts as ligand for integrin alpha-L/beta-2 which is a leukocyte adhesion peptide. Amid migration of leukocytes ICAM1 promotes endothelial apical assembly cups via activation of ARHGEF26/SGEF & RHOG.
ICAM1 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 466 amino acids (28-485 a.a) and having a molecular mass of 51.2kDa.ICAM1 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ICAM1: a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral; Immunoglobulin superfamily Cellular Component: extracellular space; cell surface; focal adhesion; membrane; integral to plasma membrane; integral to membrane; plasma membrane; immunological synapse; external side of plasma membrane; lipid raft Molecular Function:integrin binding; protein complex binding Biological Process: regulation of cell adhesion; virion attachment, binding of host cell surface receptor; negative regulation of calcium ion transport; positive regulation of nitric oxide biosynthetic process; T cell antigen processing and presentation; activation of NF-kappaB transcription factor; positive regulation of cellular extravasation; regulation of cell shape; cell-cell adhesion; leukocyte adhesion; positive regulation of peptidyl-tyrosine phosphorylation; sensory perception of sound; positive regulation of actin filament polymerization; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; positive regulation of vasoconstriction; adhesion to host; cell adhesion mediated by integrin; cell adhesion; acute inflammatory response to antigenic stimulus |
| NCBI Summary: | This gene encodes an integral membrane protein that binds leukocyte adhesion protein LFA-1. It participates in the innate immune response. [provided by RefSeq, Aug 2016] |
| UniProt Code: | P13597 |
| NCBI GenInfo Identifier: | 124099 |
| NCBI Gene ID: | 15894 |
| NCBI Accession: | P13597.1 |
| UniProt Related Accession: | P13597 |
| Molecular Weight: | |
| NCBI Full Name: | Intercellular adhesion molecule 1 |
| NCBI Synonym Full Names: | intercellular adhesion molecule 1 |
| NCBI Official Symbol: | Icam1�� |
| NCBI Official Synonym Symbols: | CD54; Ly-47; Icam-1; MALA-2�� |
| NCBI Protein Information: | intercellular adhesion molecule 1 |
| UniProt Protein Name: | Intercellular adhesion molecule 1 |
| UniProt Synonym Protein Names: | MALA-2; MyD10; CD_antigen: CD54 |
| UniProt Gene Name: | Icam1�� |
| UniProt Entry Name: | ICAM1_MOUSE |
