MMP20 Antibody (PACO20028)
- SKU:
- PACO20028
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | MMP20 Antibody (PACO20028) |
抗体コード: | PACO20028 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Synthetic peptide of human MMP20 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO20028(MMP20 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). | |
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane 1-3: 823 cells, mouse brain tissue, human fetal brain tissue, Primary antibody: PACO20028(MMP20 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. | |
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO20028(MMP20 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. |
シノニム: | matrix metallopeptidase 20 |
UniProt Protein Function: | MMP20: Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Defects in MMP20 are the cause of amelogenesis imperfecta hypomaturation type 2A2 (AI2A2). AI2A2 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel. Belongs to the peptidase M10A family. |
UniProt Protein Details: | Protein type:EC 3.4.24.-; Secreted, signal peptide; Secreted; Protease Chromosomal Location of Human Ortholog: 11q22.3 Cellular Component: extracellular region; extracellular space Molecular Function:metalloendopeptidase activity; protein binding; serine-type endopeptidase activity Biological Process: collagen catabolic process Disease: Amelogenesis Imperfecta, Hypomaturation Type, Iia2 |
NCBI Summary: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011] |
UniProt Code: | O60882 |
NCBI GenInfo Identifier: | 322510116 |
NCBI Gene ID: | 9313 |
NCBI Accession: | O60882.3 |
UniProt Secondary Accession: | O60882,Q6DKT9, |
UniProt Related Accession: | O60882 |
Molecular Weight: | 54,387 Da |
NCBI Full Name: | Matrix metalloproteinase-20 |
NCBI Synonym Full Names: | matrix metallopeptidase 20 |
NCBI Official Symbol: | MMP20 |
NCBI Official Synonym Symbols: | AI2A2; MMP-20 |
NCBI Protein Information: | matrix metalloproteinase-20 |
UniProt Protein Name: | Matrix metalloproteinase-20 |
UniProt Synonym Protein Names: | Enamel metalloproteinase; Enamelysin |
Protein Family: | Matrix metalloproteinase |
UniProt Gene Name: | MMP20 |
UniProt Entry Name: | MMP20_HUMAN |
Antibodies | ELISA Kits |
Anti-MMP20 Antibody (CAB13062) | Human Matrix metalloproteinase-20 (MMP20) ELISA Kit |
Anti-MMP20 Antibody (CAB9788) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |