| UniProt Protein Function: | KCNIP1: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface. Belongs to the recoverin family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 5q35.1 Cellular Component: voltage-gated potassium channel complex; extrinsic to internal side of plasma membrane; cell soma; cytoplasm; dendrite Molecular Function:protein binding; potassium channel regulator activity; potassium channel activity; protein heterodimerization activity; protein N-terminus binding; voltage-gated ion channel activity; calcium ion binding Biological Process: positive regulation of action potential |
| NCBI Summary: | This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013] |
| UniProt Code: | Q9NZI2 |
| NCBI GenInfo Identifier: | 73621122 |
| NCBI Gene ID: | 30820 |
| NCBI Accession: | Q9NZI2.2 |
| UniProt Secondary Accession: | Q9NZI2,Q3YAD0, Q3YAD1, Q3YAD2, Q3YAD3, Q5U822, B7Z7B4 |
| UniProt Related Accession: | Q9NZI2 |
| Molecular Weight: | 227 |
| NCBI Full Name: | Kv channel-interacting protein 1 |
| NCBI Synonym Full Names: | Kv channel interacting protein 1 |
| NCBI Official Symbol: | KCNIP1 |
| NCBI Official Synonym Symbols: | VABP; KCHIP1 |
| NCBI Protein Information: | Kv channel-interacting protein 1; vesicle APC-binding protein; potassium channel interacting protein 1; A-type potassium channel modulatory protein 1 |
| UniProt Protein Name: | Kv channel-interacting protein 1 |
| UniProt Synonym Protein Names: | A-type potassium channel modulatory protein 1; Potassium channel-interacting protein 1; Vesicle APC-binding protein |
| UniProt Gene Name: | KCNIP1 |
| UniProt Entry Name: | KCIP1_HUMAN |
