Description
| Product Name: | Human MYCBP Recombinant Protein |
| Product Code: | RPPB4028 |
| Size: | 20µg |
| Species: | Human |
| Target: | MYCBP |
| Synonyms: | C-Myc-binding protein, Associate of Myc 1, AMY-1, MYCBP, AMY1, FLJ41056. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | MYCBP protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAHYKAADSK REQFRRYLEK SGVLDTLTKV LVALYEEPEK PNSALDFLKH HLGAATPENP EIELLRLELA EMKEKYEAIV EENKKLKAKL AQYEPPQEEK RAE |
MYCBP is a member of the AMY1 family. MYCBP (c-Myc binding protein) binds to the transactivation domain of c-Myc and stimulates the activation of E-box-dependent transcription. MYCBP translocates from the cytoplasm to the nucleus during S phase when increased expression of c-Myc occurs. MYCBP also associates with AKAP 149 and AKAP 84 in mitochondria of somatic cells and sperm, suggesting a role for MYCBP in spermatogenesis. MYCBP is highly expressed in the heart, placenta, pancreas, skeletal muscle and kidney. It is also present at low levels in the lung.
MYCBP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 123 amino acids (1-103 a.a.) and having a molecular mass of 14.1kDa.MYCBP is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MYCBP: May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC. Belongs to the AMY1 family. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 1p33-p32.2 Cellular Component: centrosome; mitochondrion; cytoplasm; nucleus Molecular Function:protein binding; transcription coactivator activity Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; spermatogenesis |
| NCBI Summary: | The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q99417 |
| NCBI GenInfo Identifier: | 33112671 |
| NCBI Gene ID: | 26292 |
| NCBI Accession: | Q99417.3 |
| UniProt Secondary Accession: | Q99417,Q5TA64, Q96HE2, B2R4N0, |
| UniProt Related Accession: | Q99417 |
| Molecular Weight: | 103 |
| NCBI Full Name: | C-Myc-binding protein |
| NCBI Synonym Full Names: | MYC binding protein |
| NCBI Official Symbol: | MYCBP�� |
| NCBI Official Synonym Symbols: | AMY-1�� |
| NCBI Protein Information: | C-Myc-binding protein; associate of myc-1; c-myc binding protein |
| UniProt Protein Name: | C-Myc-binding protein |
| UniProt Synonym Protein Names: | Associate of Myc 1; AMY-1 |
| Protein Family: | MYCBP-associated protein |
| UniProt Gene Name: | MYCBP�� |
| UniProt Entry Name: | MYCBP_HUMAN |
